Effect of intraperitoneal cetuximab administration on colonic anastomosis and early postoperative adhesion formation in a rat model

We aimed to evaluate the effect of intraperitoneal cetuximab administration on the healing of anastomosis and development of early adhesion formation in a rat model. Twenty-four female rats were used. A colon segment was resected and end-to-end anastomosis was performed. The rats were randomized int...

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Bibliographic Details
Published in:Turkish journal of surgery 2016, Vol.32 (3), p.157-161
Main Authors: Kurt, Atilla, Karanlık, Hasan, Soylu, Sinan, Özgür, İlker, Soydinç, Hilal Oğuz, Duranyıldız, Derya, Olgaç, Vakur, Şen, Fatma, Asoğlu, Oktar
Format: Article
Language:English
Subjects:
Adhesion
Anesthesia
Cancer
Cancer therapies
Chemotherapy
Laboratories
Metastasis
Original Investigation
Postoperative period
Rodents
Surgery
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Summary:We aimed to evaluate the effect of intraperitoneal cetuximab administration on the healing of anastomosis and development of early adhesion formation in a rat model. Twenty-four female rats were used. A colon segment was resected and end-to-end anastomosis was performed. The rats were randomized into three groups after the performance of colonic anastomosis and received 10 mL of intraperitoneal solution including study drugs after closure of abdominal cavity: normal saline was administered to the normal saline group (n=8), cetuximab (400 mg/m(2)) was administered to the postoperative 1 group (n=8) 1 day after surgery, and cetuximab (400 mg/m(2)) was administered to the peroperative group (n=8) during surgery. The mean adhesion grade was 2.63±0.92, and 0.50±0.76 and 0.63±0.74 for control and test groups, respectively. Cetuximab reduced adhesion formation in test groups (p
ISSN:1300-0705
2564-6850
1308-8521
2564-7032
DOI:10.5152/UCD.2016.3250