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Associations Between Helminth Infections, Plasmodium falciparum Parasite Carriage and Antibody Responses to Sexual and Asexual Stage Malarial Antigens
Infections with helminths and Plasmodium spp. overlap in their geographical distribution. It has been postulated that helminth infections may influence malarial transmission by altering Plasmodium falciparum gametocytogenesis. This cross-sectional study assessed the effect of helminth infections on...
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| Published in: | The American journal of tropical medicine and hygiene 2016-08, Vol.95 (2), p.394-400 |
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| creator | Ateba-Ngoa, Ulysse Jones, Sophie Zinsou, Jeannot Fréjus Honkpehedji, Josiane Adegnika, Ayola Akim Agobe, Jean-Claude Dejon Massinga-Loembe, Marguerite Mordmüller, Benjamin Bousema, Teun Yazdanbakhsh, Maria |
| description | Infections with helminths and Plasmodium spp. overlap in their geographical distribution. It has been postulated that helminth infections may influence malarial transmission by altering Plasmodium falciparum gametocytogenesis. This cross-sectional study assessed the effect of helminth infections on P. falciparum gametocyte carriage and on humoral immune responses to sexual stage antigens in Gabon. Schistosoma haematobium and filarial infections as well as P. falciparum asexual forms and gametocyte carriage were determined. The antibody responses measured were to sexual (Pfs230, Pfs48/45) and asexual P. falciparum antigens (AMA1, MSP1, and GLURP). A total of 287 subjects were included. The prevalence of microscopically detectable P. falciparum asexual parasites was higher in S. haematobium-infected subjects in comparison to their uninfected counterparts (47% versus 26%, P = 0.003), but this was not different when filarial infections were considered. Plasmodium falciparum gametocyte carriage was similar between Schistosoma- or filaria-infected and uninfected subjects. We observed a significant decrease of Pfs48/45 immunoglobulin G titer in S. haematobium-infected subjects (P = 0.037), whereas no difference was seen for Pfs230 antibody titer, nor for antibodies to AMA1, MSP1, or GLURP. Our findings suggest an effect of S. haematobium on antibody responses to some P. falciparum gametocyte antigens that may have consequences for transmission-blocking immunity. |
| doi_str_mv | 10.4269/ajtmh.15-0703 |
| format | article |
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It has been postulated that helminth infections may influence malarial transmission by altering Plasmodium falciparum gametocytogenesis. This cross-sectional study assessed the effect of helminth infections on P. falciparum gametocyte carriage and on humoral immune responses to sexual stage antigens in Gabon. Schistosoma haematobium and filarial infections as well as P. falciparum asexual forms and gametocyte carriage were determined. The antibody responses measured were to sexual (Pfs230, Pfs48/45) and asexual P. falciparum antigens (AMA1, MSP1, and GLURP). A total of 287 subjects were included. The prevalence of microscopically detectable P. falciparum asexual parasites was higher in S. haematobium-infected subjects in comparison to their uninfected counterparts (47% versus 26%, P = 0.003), but this was not different when filarial infections were considered. Plasmodium falciparum gametocyte carriage was similar between Schistosoma- or filaria-infected and uninfected subjects. We observed a significant decrease of Pfs48/45 immunoglobulin G titer in S. haematobium-infected subjects (P = 0.037), whereas no difference was seen for Pfs230 antibody titer, nor for antibodies to AMA1, MSP1, or GLURP. Our findings suggest an effect of S. haematobium on antibody responses to some P. falciparum gametocyte antigens that may have consequences for transmission-blocking immunity.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.15-0703</identifier><identifier>PMID: 27273645</identifier><language>eng</language><publisher>United States: The American Society of Tropical Medicine and Hygiene</publisher><subject>Adolescent ; Animals ; Antibodies, Protozoan - biosynthesis ; Antigens, Protozoan - genetics ; Antigens, Protozoan - immunology ; Child ; Coinfection ; Cross-Sectional Studies ; Female ; Gabon - epidemiology ; Gene Expression ; Humans ; Immunity, Humoral ; Life Cycle Stages - genetics ; Life Cycle Stages - immunology ; Malaria, Falciparum - epidemiology ; Malaria, Falciparum - immunology ; Malaria, Falciparum - parasitology ; Male ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - immunology ; Membrane Proteins - genetics ; Membrane Proteins - immunology ; Merozoite Surface Protein 1 - genetics ; Merozoite Surface Protein 1 - immunology ; Plasmodium falciparum ; Plasmodium falciparum - genetics ; Plasmodium falciparum - growth & development ; Plasmodium falciparum - immunology ; Protozoan Proteins - genetics ; Protozoan Proteins - immunology ; Schistosoma haematobium ; Schistosoma haematobium - genetics ; Schistosoma haematobium - growth & development ; Schistosoma haematobium - immunology ; Schistosomiasis haematobia - epidemiology ; Schistosomiasis haematobia - immunology ; Schistosomiasis haematobia - parasitology</subject><ispartof>The American journal of tropical medicine and hygiene, 2016-08, Vol.95 (2), p.394-400</ispartof><rights>The American Society of Tropical Medicine and Hygiene.</rights><rights>The American Society of Tropical Medicine and Hygiene 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-7909bbba603b27fa8ecbeeb1c30fc0a941222e905395bebef842afc3ca5fe3113</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973188/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973188/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27273645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ateba-Ngoa, Ulysse</creatorcontrib><creatorcontrib>Jones, Sophie</creatorcontrib><creatorcontrib>Zinsou, Jeannot Fréjus</creatorcontrib><creatorcontrib>Honkpehedji, Josiane</creatorcontrib><creatorcontrib>Adegnika, Ayola Akim</creatorcontrib><creatorcontrib>Agobe, Jean-Claude Dejon</creatorcontrib><creatorcontrib>Massinga-Loembe, Marguerite</creatorcontrib><creatorcontrib>Mordmüller, Benjamin</creatorcontrib><creatorcontrib>Bousema, Teun</creatorcontrib><creatorcontrib>Yazdanbakhsh, Maria</creatorcontrib><title>Associations Between Helminth Infections, Plasmodium falciparum Parasite Carriage and Antibody Responses to Sexual and Asexual Stage Malarial Antigens</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>Infections with helminths and Plasmodium spp. overlap in their geographical distribution. It has been postulated that helminth infections may influence malarial transmission by altering Plasmodium falciparum gametocytogenesis. This cross-sectional study assessed the effect of helminth infections on P. falciparum gametocyte carriage and on humoral immune responses to sexual stage antigens in Gabon. Schistosoma haematobium and filarial infections as well as P. falciparum asexual forms and gametocyte carriage were determined. The antibody responses measured were to sexual (Pfs230, Pfs48/45) and asexual P. falciparum antigens (AMA1, MSP1, and GLURP). A total of 287 subjects were included. The prevalence of microscopically detectable P. falciparum asexual parasites was higher in S. haematobium-infected subjects in comparison to their uninfected counterparts (47% versus 26%, P = 0.003), but this was not different when filarial infections were considered. Plasmodium falciparum gametocyte carriage was similar between Schistosoma- or filaria-infected and uninfected subjects. We observed a significant decrease of Pfs48/45 immunoglobulin G titer in S. haematobium-infected subjects (P = 0.037), whereas no difference was seen for Pfs230 antibody titer, nor for antibodies to AMA1, MSP1, or GLURP. Our findings suggest an effect of S. haematobium on antibody responses to some P. falciparum gametocyte antigens that may have consequences for transmission-blocking immunity.</description><subject>Adolescent</subject><subject>Animals</subject><subject>Antibodies, Protozoan - biosynthesis</subject><subject>Antigens, Protozoan - genetics</subject><subject>Antigens, Protozoan - immunology</subject><subject>Child</subject><subject>Coinfection</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Gabon - epidemiology</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Immunity, Humoral</subject><subject>Life Cycle Stages - genetics</subject><subject>Life Cycle Stages - immunology</subject><subject>Malaria, Falciparum - epidemiology</subject><subject>Malaria, Falciparum - immunology</subject><subject>Malaria, Falciparum - parasitology</subject><subject>Male</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Membrane Glycoproteins - immunology</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - immunology</subject><subject>Merozoite Surface Protein 1 - genetics</subject><subject>Merozoite Surface Protein 1 - immunology</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - genetics</subject><subject>Plasmodium falciparum - growth & development</subject><subject>Plasmodium falciparum - immunology</subject><subject>Protozoan Proteins - genetics</subject><subject>Protozoan Proteins - immunology</subject><subject>Schistosoma haematobium</subject><subject>Schistosoma haematobium - genetics</subject><subject>Schistosoma haematobium - growth & development</subject><subject>Schistosoma haematobium - immunology</subject><subject>Schistosomiasis haematobia - epidemiology</subject><subject>Schistosomiasis haematobia - immunology</subject><subject>Schistosomiasis haematobia - parasitology</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkU9v1DAQxS0EokvhyBX5yIEU_0ni-IK0rIBWKqKicLbG3smuq8RebAfoF-Hzkt0tFdw4zUjze29m9Ah5ztlZLVr9Gm7KuD3jTcUUkw_IgteqrXhbNw_JgjEmKt1KdUKe5HzDGO8E54_JiVBCyZlZkF_LnKPzUHwMmb7F8gMx0HMcRh_Kll6EHt1h9opeDZDHuPbTSHsYnN9BmtsrSJB9QbqClDxskEJY02Uo3sb1Lf2MeTerMdMS6TX-nGA4AvnYX5e95CMMMIuHg26DIT8lj-YdGZ_d1VPy9f27L6vz6vLTh4vV8rJytWalUpppay20TFqheujQWUTLnWS9Y6BrLoRAzRqpG4sW-64W0DvpoOlRci5PyZuj726yI64dhpJgMLvkR0i3JoI3_06C35pN_G5qrSTvutng5Z1Bit8mzMWMPjscBggYp2x4xxvFOv1fKNMtE6yrZ7Q6oi7FnBP29xdxZvaxm0PshjdmH_vMv_j7jXv6T87yN_BOrlA</recordid><startdate>20160803</startdate><enddate>20160803</enddate><creator>Ateba-Ngoa, Ulysse</creator><creator>Jones, Sophie</creator><creator>Zinsou, Jeannot Fréjus</creator><creator>Honkpehedji, Josiane</creator><creator>Adegnika, Ayola Akim</creator><creator>Agobe, Jean-Claude Dejon</creator><creator>Massinga-Loembe, Marguerite</creator><creator>Mordmüller, Benjamin</creator><creator>Bousema, Teun</creator><creator>Yazdanbakhsh, Maria</creator><general>The American Society of Tropical Medicine and Hygiene</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope><scope>5PM</scope></search><sort><creationdate>20160803</creationdate><title>Associations Between Helminth Infections, Plasmodium falciparum Parasite Carriage and Antibody Responses to Sexual and Asexual Stage Malarial Antigens</title><author>Ateba-Ngoa, Ulysse ; Jones, Sophie ; Zinsou, Jeannot Fréjus ; Honkpehedji, Josiane ; Adegnika, Ayola Akim ; Agobe, Jean-Claude Dejon ; Massinga-Loembe, Marguerite ; Mordmüller, Benjamin ; Bousema, Teun ; Yazdanbakhsh, Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-7909bbba603b27fa8ecbeeb1c30fc0a941222e905395bebef842afc3ca5fe3113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Animals</topic><topic>Antibodies, Protozoan - biosynthesis</topic><topic>Antigens, Protozoan - genetics</topic><topic>Antigens, Protozoan - immunology</topic><topic>Child</topic><topic>Coinfection</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Gabon - epidemiology</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Immunity, Humoral</topic><topic>Life Cycle Stages - genetics</topic><topic>Life Cycle Stages - immunology</topic><topic>Malaria, Falciparum - epidemiology</topic><topic>Malaria, Falciparum - immunology</topic><topic>Malaria, Falciparum - parasitology</topic><topic>Male</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Membrane Glycoproteins - immunology</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - immunology</topic><topic>Merozoite Surface Protein 1 - genetics</topic><topic>Merozoite Surface Protein 1 - immunology</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - genetics</topic><topic>Plasmodium falciparum - growth & development</topic><topic>Plasmodium falciparum - immunology</topic><topic>Protozoan Proteins - genetics</topic><topic>Protozoan Proteins - immunology</topic><topic>Schistosoma haematobium</topic><topic>Schistosoma haematobium - genetics</topic><topic>Schistosoma haematobium - growth & development</topic><topic>Schistosoma haematobium - immunology</topic><topic>Schistosomiasis haematobia - epidemiology</topic><topic>Schistosomiasis haematobia - immunology</topic><topic>Schistosomiasis haematobia - parasitology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ateba-Ngoa, Ulysse</creatorcontrib><creatorcontrib>Jones, Sophie</creatorcontrib><creatorcontrib>Zinsou, Jeannot Fréjus</creatorcontrib><creatorcontrib>Honkpehedji, Josiane</creatorcontrib><creatorcontrib>Adegnika, Ayola Akim</creatorcontrib><creatorcontrib>Agobe, Jean-Claude Dejon</creatorcontrib><creatorcontrib>Massinga-Loembe, Marguerite</creatorcontrib><creatorcontrib>Mordmüller, Benjamin</creatorcontrib><creatorcontrib>Bousema, Teun</creatorcontrib><creatorcontrib>Yazdanbakhsh, Maria</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ateba-Ngoa, Ulysse</au><au>Jones, Sophie</au><au>Zinsou, Jeannot Fréjus</au><au>Honkpehedji, Josiane</au><au>Adegnika, Ayola Akim</au><au>Agobe, Jean-Claude Dejon</au><au>Massinga-Loembe, Marguerite</au><au>Mordmüller, Benjamin</au><au>Bousema, Teun</au><au>Yazdanbakhsh, Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations Between Helminth Infections, Plasmodium falciparum Parasite Carriage and Antibody Responses to Sexual and Asexual Stage Malarial Antigens</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2016-08-03</date><risdate>2016</risdate><volume>95</volume><issue>2</issue><spage>394</spage><epage>400</epage><pages>394-400</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><abstract>Infections with helminths and Plasmodium spp. overlap in their geographical distribution. It has been postulated that helminth infections may influence malarial transmission by altering Plasmodium falciparum gametocytogenesis. This cross-sectional study assessed the effect of helminth infections on P. falciparum gametocyte carriage and on humoral immune responses to sexual stage antigens in Gabon. Schistosoma haematobium and filarial infections as well as P. falciparum asexual forms and gametocyte carriage were determined. The antibody responses measured were to sexual (Pfs230, Pfs48/45) and asexual P. falciparum antigens (AMA1, MSP1, and GLURP). A total of 287 subjects were included. The prevalence of microscopically detectable P. falciparum asexual parasites was higher in S. haematobium-infected subjects in comparison to their uninfected counterparts (47% versus 26%, P = 0.003), but this was not different when filarial infections were considered. Plasmodium falciparum gametocyte carriage was similar between Schistosoma- or filaria-infected and uninfected subjects. We observed a significant decrease of Pfs48/45 immunoglobulin G titer in S. haematobium-infected subjects (P = 0.037), whereas no difference was seen for Pfs230 antibody titer, nor for antibodies to AMA1, MSP1, or GLURP. Our findings suggest an effect of S. haematobium on antibody responses to some P. falciparum gametocyte antigens that may have consequences for transmission-blocking immunity.</abstract><cop>United States</cop><pub>The American Society of Tropical Medicine and Hygiene</pub><pmid>27273645</pmid><doi>10.4269/ajtmh.15-0703</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Animals Antibodies, Protozoan - biosynthesis Antigens, Protozoan - genetics Antigens, Protozoan - immunology Child Coinfection Cross-Sectional Studies Female Gabon - epidemiology Gene Expression Humans Immunity, Humoral Life Cycle Stages - genetics Life Cycle Stages - immunology Malaria, Falciparum - epidemiology Malaria, Falciparum - immunology Malaria, Falciparum - parasitology Male Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Membrane Proteins - genetics Membrane Proteins - immunology Merozoite Surface Protein 1 - genetics Merozoite Surface Protein 1 - immunology Plasmodium falciparum Plasmodium falciparum - genetics Plasmodium falciparum - growth & development Plasmodium falciparum - immunology Protozoan Proteins - genetics Protozoan Proteins - immunology Schistosoma haematobium Schistosoma haematobium - genetics Schistosoma haematobium - growth & development Schistosoma haematobium - immunology Schistosomiasis haematobia - epidemiology Schistosomiasis haematobia - immunology Schistosomiasis haematobia - parasitology |
| title | Associations Between Helminth Infections, Plasmodium falciparum Parasite Carriage and Antibody Responses to Sexual and Asexual Stage Malarial Antigens |
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