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Human eosinophils modulate peripheral blood mononuclear cell response to Schistosoma mansoni adult worm antigen in vitro

Summary High numbers of eosinophils are observed in parasitic infections and allergic diseases, where they are proposed to be terminally differentiated effector cells that play beneficial role in host defence, or cause harmful inflammatory response. Eosinophils have been associated with killing of s...

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Bibliographic Details
Published in:Parasite immunology 2016-08, Vol.38 (8), p.516-522
Main Authors: Tweyongyere, R., Namanya, H., Naniima, P., Cose, S., Tukahebwa, E. M., Elliott, A. M., Dunne, D. W., Wilson, S.
Format: Article
Language:English
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Summary:Summary High numbers of eosinophils are observed in parasitic infections and allergic diseases, where they are proposed to be terminally differentiated effector cells that play beneficial role in host defence, or cause harmful inflammatory response. Eosinophils have been associated with killing of schistosomulae in vitro, but there is growing evidence that eosinophils can play additional immuno‐regulatory role. Here, we report results of a study that examines peripheral blood mononuclear cell (PBMC) cytokine responses to Schistosoma mansoni adult worm antigen (SWA) when stimulated alone or enriched with autologous eosinophils. Production of the Th‐2 type cytokines interleukin (IL)‐4, IL‐5 and IL‐13 was lower (P = 0·017, 0·018 and
ISSN:0141-9838
1365-3024
DOI:10.1111/pim.12336