Soya protein antibodies in man: their occurrence and possible relevance in coeliac disease

Circulating antibodies to soya-derived protein antigens have been measured in patients with duodenitis, Crohn's disease, ulcerative colitis and coeliac disease. Significantly raised antibody titres were found frequently in the coeliac group, particularly those patients showing a suboptimal resp...

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Bibliographic Details
Published in:Journal of clinical pathology 1982-03, Vol.35 (3), p.319-322
Main Authors: Haeney, M R, Goodwin, B J, Barratt, M E, Mike, N, Asquith, P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibodies - analysis
Celiac Disease - diet therapy
Celiac Disease - immunology
Dietary Proteins
Enzyme-Linked Immunosorbent Assay
Female
Fluorescent Antibody Technique
Gastrointestinal Diseases - immunology
Glycine max
Hemagglutination
Humans
Immunoglobulin G - analysis
Male
Middle Aged
Plant Proteins - immunology
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Description
Summary:Circulating antibodies to soya-derived protein antigens have been measured in patients with duodenitis, Crohn's disease, ulcerative colitis and coeliac disease. Significantly raised antibody titres were found frequently in the coeliac group, particularly those patients showing a suboptimal response to a gluten-free diet, but rarely in subjects with other gastrointestinal diseases. Antisoya activity was not necessarily accompanied by antibodies to other common dietary antigens. We suggest that some coeliacs may have an associated dietary soya sensitivity which could adversely influence their response to gluten withdrawal.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.35.3.319