Stria vascularis and cochlear hair cell changes in syphilis: A human temporal bone study

• Published in: Auris, nasus, larynx nasus, larynx, 2016-12, Vol.43 (6), p.614-619
• Main Authors: Hızlı, Ömer, Kaya, Serdar, Hızlı, Pelin, Paparella, Michael M, Cureoglu, Sebahattin
• Format: Article
• Language: English
• Subjects: Aged; Case-Control Studies; Cell Count; Cochlea; Cochlea - pathology; Ear, Inner - pathology; Endolymphatic Duct - pathology; Endolymphatic Hydrops - etiology; Endolymphatic Hydrops - pathology; Female; Hair cell; Hair Cells, Auditory - pathology; Histopathology; Humans; Male; Middle Aged; Organ of Corti - pathology; Organ Size; Otolaryngology; Stria Vascularis - pathology; Syphilis; Syphilis - complications; Syphilis - pathology; Temporal bone; Temporal Bone - pathology
• ISSN: 0385-8146; 1879-1476
• DOI: 10.1016/j.anl.2016.01.001

Abstract Objective To observe any changes in stria vascularis and cochlear hair cells in patients with syphilis. Materials and methods We examined 13 human temporal bone samples from 8 patients with syphilis (our syphilis group), as well as 12 histopathologically normal samples from 9 age-matched patients without syphilis (our control group). We compared, between the two groups, the mean area of the stria vascularis (measured with conventional light microscopy connected to a personal computer) and the mean percentage of cochlear hair cell loss (obtained from cytocochleograms). Results In our syphilis group, only 1 (7.7%) of the 13 samples had precipitate in the endolymphatic or perilymphatic spaces; 8 (61.5%) of the samples revealed the presence of endolymphatic hydrops (4 cochlear, 4 saccular). The mean area of the stria vascularis did not significantly differ, in any turn of the cochlea, between the 2 groups ( P > 0.1). However, we did find significant differences between the 2 groups in the mean percentage of outer hair cells in the apical turn ( P < 0.026) and in the mean percentage of inner hair cells in the basal ( P = 0.001), middle ( P = 0.004), and apical ( P = 0.018) turns. In 7 samples in our syphilis group, we observed either complete loss of the organ of Corti or a flattened organ of Corti without any cells in addition to the absence of both outer and inner hair cells. Conclusion In this study, syphilis led either to complete loss of the organ of Corti or to significant loss of cochlear hair cells, in addition to cochleosaccular hydrops. But the area of the stria vascularis did not change.