Oxygen extraction fraction measurement using quantitative susceptibility mapping: Comparison with positron emission tomography

The purposes of this study are to establish oxygen extraction fraction (OEF) measurements using quantitative susceptibility mapping (QSM) of magnetic resonance imaging (MRI), and to compare QSM–OEF data with the gold standard 15O positron emission tomography (PET). Twenty-six patients with chronic u...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 2016-08, Vol.36 (8), p.1424-1433
Main Authors: Kudo, Kohsuke, Liu, Tian, Murakami, Toshiyuki, Goodwin, Jonathan, Uwano, Ikuko, Yamashita, Fumio, Higuchi, Satomi, Wang, Yi, Ogasawara, Kuniaki, Ogawa, Akira, Sasaki, Makoto
Format: Article
Language:English
Subjects:
Adult
Aged
Brain - blood supply
Brain - diagnostic imaging
Brain Mapping - methods
Carotid Stenosis - diagnostic imaging
Carotid Stenosis - metabolism
Carotid Stenosis - physiopathology
Cerebrovascular Circulation - physiology
Female
Humans
Infarction, Middle Cerebral Artery - diagnostic imaging
Infarction, Middle Cerebral Artery - metabolism
Infarction, Middle Cerebral Artery - physiopathology
Magnetic Resonance Imaging - methods
Male
Middle Aged
Original
Oxygen - analysis
Oxygen Consumption - physiology
Positron-Emission Tomography - methods
Young Adult
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Summary:The purposes of this study are to establish oxygen extraction fraction (OEF) measurements using quantitative susceptibility mapping (QSM) of magnetic resonance imaging (MRI), and to compare QSM–OEF data with the gold standard 15O positron emission tomography (PET). Twenty-six patients with chronic unilateral internal carotid artery or middle cerebral artery stenosis or occlusion, and 15 normal subjects were included. MRI scans were conducted using a 3.0 Tesla scanner with a three-dimensional spoiled gradient recalled sequence. QSM images were created using the morphology-enabled dipole inversion method, and OEF maps were generated from QSM images using extraction of venous susceptibility induced by deoxygenated hemoglobin. Significant correlation of relative OEF ratio to contra-lateral hemisphere between QSM–OEF and PET–OEF was observed (r = 0.62, p 
ISSN:0271-678X
1559-7016
DOI:10.1177/0271678X15606713