Determination of GP88 (progranulin) expression in breast tumor biopsies improves the risk predictive value of the Nottingham Prognostic Index

The Nottingham Prognostic Index (NPI), which combines numerical values for nodal status, tumor size and histological grade, is used in the standard of care to provide predictive value information on post-surgery survival for patients with primary breast cancer. Attempts to improve the performance of...

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Bibliographic Details
Published in:Diagnostic pathology 2016-08, Vol.11 (1), p.71-71, Article 71
Main Authors: Serrero, Ginette, Hawkins, Douglas M, Bejarano, Pablo A, Ioffe, Olga, Tkaczuk, Katherine R, Elliott, Robert E, Head, Jonathan F, Phillips, Jeffrey, Godwin, Andrew K, Weaver, JoEllen, Hicks, David, Yue, Binbin
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological markers
Biomarkers, Tumor - metabolism
Biopsy
Breast - pathology
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - metabolism
Breast Neoplasms - mortality
Care and treatment
Estrogen
Female
Gene expression
Humans
Immunohistochemistry
Intercellular Signaling Peptides and Proteins - metabolism
Kaplan-Meier Estimate
Middle Aged
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Receptors, Estrogen - metabolism
Retrospective Studies
Young Adult
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Summary:The Nottingham Prognostic Index (NPI), which combines numerical values for nodal status, tumor size and histological grade, is used in the standard of care to provide predictive value information on post-surgery survival for patients with primary breast cancer. Attempts to improve the performance of the NPI algorithm have been carried out by testing the inclusion of other biomarker expression and morphological features such as vascular invasion. In the present study, we investigated whether expression of the autocrine growth and survival factor GP88 (progranulin), known to be overexpressed in breast cancer, would improve NPI's predictive value. We examined by immunohistochemistry (IHC) the GP88 expression in 508 cases of estrogen receptor positive invasive ductal carcinoma with known clinical outcomes and for which NPI had been determined. GP88 IHC expression was scored by two board certified pathologists and classified into two score groups of GP88
ISSN:1746-1596
1746-1596
DOI:10.1186/s13000-016-0520-4