Iontophoresis-Assisted Corneal Collagen Cross-Linking with Epithelial Debridement: Preliminary Results

Purpose. To report the early outcomes of iontophoresis-assisted corneal collagen cross-linking procedure with epithelial debridement (I-SCXL). Methods. Twenty eyes of twenty patients with progressive keratoconus were included in this prospective clinical study. Best spectacle corrected visual acuity...

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Bibliographic Details
Published in:BioMed research international 2016-01, Vol.2016 (2016), p.1-5
Main Authors: Vinciguerra, Riccardo, Kubrak-Kisza, Magdalena, Legrottaglie, Emanuela F., Rosetta, Pietro, Romano, Vito, Vinciguerra, Paolo, Azzolini, Claudio
Format: Article
Language:English
Subjects:
Adult
Biomedical research
Clinical Study
Collagen
Contact lenses
Cornea - diagnostic imaging
Endothelial Cells - cytology
Female
Humans
Iontophoresis - methods
Keratoconus - diagnostic imaging
Keratoconus - therapy
Male
Middle Aged
Prospective Studies
Surgery
Tomography
Vision Tests
Vitamin B
Young Adult
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Summary:Purpose. To report the early outcomes of iontophoresis-assisted corneal collagen cross-linking procedure with epithelial debridement (I-SCXL). Methods. Twenty eyes of twenty patients with progressive keratoconus were included in this prospective clinical study. Best spectacle corrected visual acuity (BSCVA), sphere and cylinder refraction, corneal topography, Scheimpflug tomography, aberrometry, anterior segment optical coherence tomography (AS-OCT), and endothelial cell count were assessed at baseline and at 1, 3, and 6 months of follow-up. The parameters considered to establish keratoconus progression were always proven with differential maps as change in curvature in the cone area of at least 1 diopter obtained with an instantaneous map. Results. Functional parameters showed a significant improvement ( p < 0.05 ) of BSCVA after 3 and 6 months of follow-up. Morphological parameters indicated stabilization of the corneal ectasia during the follow-up; however, a positive trend was noted with a mean flattening of 1.73 D. Minimum pachymetry values showed thinning that remained constant after the treatment. The demarcation line was clearly visible in all patients, reaching a depth of 308.2 ± 37.74 μm. None of the patients had continuous progression of keratoconus or had to repeat cross-linking procedures. Endothelial cell counts did not change significantly ( p > 0.05 ). Conclusion. The early results indicate that the I-SCXL may be able to reduce the treatment time and improve the riboflavin diffusion.
ISSN:2314-6133
2314-6141
DOI:10.1155/2016/3720517