Osteomalacia and osteoporosis: evaluation of a diagnostic index

Data from a retrospective study in 41 patients is used to suggest an index of bone disease. This is designed as a means of collating available results, clarifying the significance of each in diagnosing either osteomalacia or osteoporosis, and reducing the significance of a single abnormal finding--f...

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Bibliographic Details
Published in:Journal of clinical pathology 1983-03, Vol.36 (3), p.245-252
Main Authors: McKenna, M J, Freaney, R, Casey, O M, Towers, R P, Muldowney, F P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Diagnosis, Differential
Evaluation Studies as Topic
Female
Humans
Male
Methods
Middle Aged
Osteomalacia - diagnosis
Osteoporosis - diagnosis
Probability
Retrospective Studies
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Summary:Data from a retrospective study in 41 patients is used to suggest an index of bone disease. This is designed as a means of collating available results, clarifying the significance of each in diagnosing either osteomalacia or osteoporosis, and reducing the significance of a single abnormal finding--for example, a raised alkaline phosphatase activity or low serum 25 hydroxy vitamin D, when the overall index score is low. Index scores above 35% would be diagnostic of osteomalacia; scores below 15% if associated with collapsed vertebrae suggest osteoporosis. Scores between 15% and 35% would indicate the need for a bone biopsy to discriminate between osteoporosis and osteomalacia.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.36.3.245