Biologic predictors of serologic responses to HPV in oropharyngeal cancer: The HOTSPOT study

Highlights • Abs to the HPV16 proteome were measured in 116 cases of OPC and 81 controls. • Serum Abs to HPV16 early Ags were detected in 90.6% of HPVOPC cases and 7.4% of controls. • Seropositivity to E6 and E2 was associated with oral HPV 16 copy number.

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Bibliographic Details
Published in:Oral oncology 2015-08, Vol.51 (8), p.751-758
Main Authors: Anderson, Karen S, Gerber, Jennifer E, D’Souza, Gypsyamber, Pai, Sara I, Cheng, Julia N, Alam, Rizwan, Kesiraju, Sailaja, Chowell, Diego, Gross, Neil D, Haddad, Robert, Gillison, Maura L, Posner, Marshall
Format: Article
Language:English
Subjects:
Adult
Antibodies
Antibodies, Viral - blood
Biomarker
Biomarkers, Tumor - blood
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Female
Hematology, Oncology and Palliative Medicine
HPV
Human papillomavirus 16 - immunology
Humans
Immunoglobulin G - blood
Male
Middle Aged
Oropharyngeal cancer
Oropharyngeal Neoplasms - virology
Otolaryngology
Papillomavirus Infections - virology
Real-Time Polymerase Chain Reaction
Risk Factors
Serology
Sexual Partners
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Summary:Highlights • Abs to the HPV16 proteome were measured in 116 cases of OPC and 81 controls. • Serum Abs to HPV16 early Ags were detected in 90.6% of HPVOPC cases and 7.4% of controls. • Seropositivity to E6 and E2 was associated with oral HPV 16 copy number.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2015.05.007