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Biologic predictors of serologic responses to HPV in oropharyngeal cancer: The HOTSPOT study

Highlights • Abs to the HPV16 proteome were measured in 116 cases of OPC and 81 controls. • Serum Abs to HPV16 early Ags were detected in 90.6% of HPVOPC cases and 7.4% of controls. • Seropositivity to E6 and E2 was associated with oral HPV 16 copy number.

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Published in:	Oral oncology 2015-08, Vol.51 (8), p.751-758
Main Authors:	Anderson, Karen S, Gerber, Jennifer E, D’Souza, Gypsyamber, Pai, Sara I, Cheng, Julia N, Alam, Rizwan, Kesiraju, Sailaja, Chowell, Diego, Gross, Neil D, Haddad, Robert, Gillison, Maura L, Posner, Marshall
Format:	Article
Language:	English
Subjects:	Adult Antibodies Antibodies, Viral - blood Biomarker Biomarkers, Tumor - blood Case-Control Studies Enzyme-Linked Immunosorbent Assay Female Hematology, Oncology and Palliative Medicine HPV Human papillomavirus 16 - immunology Humans Immunoglobulin G - blood Male Middle Aged Oropharyngeal cancer Oropharyngeal Neoplasms - virology Otolaryngology Papillomavirus Infections - virology Real-Time Polymerase Chain Reaction Risk Factors Serology Sexual Partners
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description	Highlights • Abs to the HPV16 proteome were measured in 116 cases of OPC and 81 controls. • Serum Abs to HPV16 early Ags were detected in 90.6% of HPVOPC cases and 7.4% of controls. • Seropositivity to E6 and E2 was associated with oral HPV 16 copy number.
doi_str_mv	10.1016/j.oraloncology.2015.05.007
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subjects	Adult Antibodies Antibodies, Viral - blood Biomarker Biomarkers, Tumor - blood Case-Control Studies Enzyme-Linked Immunosorbent Assay Female Hematology, Oncology and Palliative Medicine HPV Human papillomavirus 16 - immunology Humans Immunoglobulin G - blood Male Middle Aged Oropharyngeal cancer Oropharyngeal Neoplasms - virology Otolaryngology Papillomavirus Infections - virology Real-Time Polymerase Chain Reaction Risk Factors Serology Sexual Partners
title	Biologic predictors of serologic responses to HPV in oropharyngeal cancer: The HOTSPOT study
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