Larva migrans syndrome caused by Toxocara and Ascaris roundworm infections in Japanese patients

• Published in: European journal of clinical microbiology & infectious diseases 2016-09, Vol.35 (9), p.1521-1529
• Main Authors: Yoshida, A., Hombu, A., Wang, Z., Maruyama, H.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Adults; Age Factors; Aged; Aged, 80 and over; Animals; Antibodies; Antigens; Ascaris; Ascaris - isolation & purification; Biomedical and Life Sciences; Biomedicine; Biopsy; Blood; Cerebrospinal fluid; Child; Child, Preschool; Eggs; Female; Females; Humans; Infections; Internal Medicine; Japan - epidemiology; Larva Migrans - epidemiology; Larva Migrans - parasitology; Larva Migrans - pathology; Male; Males; Meat; Medical imaging; Medical Microbiology; Middle Aged; Original; Original Article; Parasites; Parasitic diseases; Pathology; Patients; Pleural effusion; Retrospective Studies; Sex ratio; Spinal cord; Toxocara; Toxocara - isolation & purification; Young Adult; Zoonoses
• ISSN: 0934-9723; 1435-4373
• DOI: 10.1007/s10096-016-2693-x

Larva migrans syndrome (LMS) caused by Toxocara and Ascaris roundworms is generally believed to be more common in children, while a report from Japan suggests that it is more common in adults. We conducted a large-scale retrospective study to confirm these findings and to clarify what caused the difference between Japan and other countries, to reveal overlooked aspects of this disease. The clinical information of 911 cases which we diagnosed as Toxocara or Ascaris LMS during 2001 and 2015 was analysed. Information used included age, sex, address (city or county), chief complaint, present history, dietary history, overseas travelling history, medical imaging findings and laboratory data (white blood cell count, peripheral blood eosinophil number and total IgE). The sex ratio of the disease was 2.37 (male/female = 641/270). The number of patients not younger than 20 years old were 97.8 and 95.1 % among males and females, respectively. Major disease types were visceral, ocular, neural and asymptomatic. The visceral type was more prevalent in older patients, while younger patients were more vulnerable to ocular symptoms. More than two-thirds of the patients whose dietary habits were recorded had a history of ingesting raw or undercooked animal meat. LMS caused by Toxocara or Ascaris is primarily a disease of adult males in Japan, who probably acquired infections by eating raw or undercooked animal meat/liver. Healthcare specialists should draw public attention to the risk of raw or undercooked animal meat in Europe as well.