Exponential apparent diffusion coefficient in evaluating prostate cancer at 3 T: preliminary experience

• Published in: British journal of radiology 2016, Vol.89 (1058), p.20150470-20150470
• Main Authors: Park, Sung Y, Kim, Chan K, Park, Jung J, Park, Byung K
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Diffusion Magnetic Resonance Imaging - methods; Feasibility Studies; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Male; Middle Aged; Neoplasm Grading; Prostatic Neoplasms - pathology; Prostatic Neoplasms - surgery; Retrospective Studies
• ISSN: 0007-1285; 1748-880X
• DOI: 10.1259/bjr.20150470

To investigate the feasibility of exponential apparent diffusion coefficient (eADC) derived from diffusion-weighted imaging (DWI) in evaluating prostate cancers at 3 T. 74 consecutive patients with surgically confirmed single peripheral zone (PZ) prostate cancer ≥0.5 cm(3) who underwent pre-operative DWI at 3 T were retrospectively selected. Based on radiological-pathological correlation, eADC and apparent diffusion coefficient (ADC) (×10(-3) mm(2) s(-1)) for the cancers and benign PZ were measured by two independent readers. Tumour eADC or ADC was correlated with Gleason score. Receiver operating characteristic curve analysis was performed to differentiate between Gleason score 6 and 7 or higher, by eADC and ADC. Lesion-to-background contrast ratio was compared between eADC and ADC. Mean tumour eADC (0.48-0.50) and ADC (0.72-0.75) were significantly different from those of benign PZ (eADC, 0.20-0.27; ADC, 1.34-1.66), respectively (p  0.05). Lesion-to-background contrast ratio of eADC (Reader 1, 2.43; Reader 2, 2.23) was significantly greater than that of ADC (Reader 1, 2.21; Reader 2, 2.12) (p