Relationship between depressive symptoms, alcohol use, and antiretroviral therapy adherence among HIV-infected, clinic-attending patients in South Africa

Despite the prevalence of depression and alcohol use among HIV-infected individuals, few studies have examined their association together in relation to nonadherence to antiretroviral therapy in sub-Saharan Africa. This study examined depressive symptoms, alcohol use, and other psychosocial factors...

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Bibliographic Details
Published in:Journal of health psychology 2017-09, Vol.22 (11), p.1426-1433
Main Authors: Magidson, Jessica F, Saal, Wylene, Nel, Adriaan, Remmert, Jocelyn E, Kagee, Ashraf
Format: Article
Language:English
Subjects:
Adherence
Adolescent
Adult
Aged
Aged, 80 and over
Alcohol Drinking - psychology
Alcohol use
Anti-HIV Agents - therapeutic use
Antiretroviral drugs
Antiretroviral therapy
Cross-Sectional Studies
Demography
Depression - psychology
Dosage
Drug therapy
Female
HIV
HIV Infections - drug therapy
HIV Infections - psychology
Human immunodeficiency virus
Humans
Logistic Models
Male
Measurement
Medication Adherence - psychology
Mental depression
Middle Aged
Psychosocial factors
South Africa
Stigma
Young Adult
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Summary:Despite the prevalence of depression and alcohol use among HIV-infected individuals, few studies have examined their association together in relation to nonadherence to antiretroviral therapy in sub-Saharan Africa. This study examined depressive symptoms, alcohol use, and other psychosocial factors (stigma, demographic characteristics) in relation to nonadherence to antiretroviral therapy among clinic-attending, HIV-infected individuals in South Africa (n = 101). Nonadherence was assessed using event-level measurement (missed doses over the past weekend). Multivariable logistic regression analyses revealed that only alcohol use, over and above depressive symptoms and education level, was associated with antiretroviral therapy nonadherence(AOR = 1.15; 95%CI = 1.02–1.29; p 
ISSN:1359-1053
1461-7277
DOI:10.1177/1359105316628743