Microdeposits of amyloid in sclerocalcific heart valves: a histochemical and immunofluorescence study

Amyloid associated with seven sclerotic and two normal aortic and mitral valves was studied. The sclerotic valve amyloid contained microfibrils with typical random orientation and a fibril width of 9.5-12.5 nm. The amyloid deposits demonstrated permanganate-resistant Congophilia and contained the am...

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Bibliographic Details
Published in:Journal of clinical pathology 1983-12, Vol.36 (12), p.1342-1349
Main Authors: Goffin, Y A, Murdoch, W, Cornwell, G G, Sorenson, G D
Format: Article
Language:English
Subjects:
Adult
Aged
Amyloid - analysis
Amyloidosis
Amyloidosis - pathology
Aortic Valve - ultrastructure
Biological and medical sciences
Calcinosis - pathology
Female
Fluorescent Antibody Technique
Heart Valve Diseases - pathology
Humans
Male
Medical sciences
Metabolic diseases
Microscopy, Electron
Middle Aged
Mitral Valve - ultrastructure
Other metabolic disorders
Sclerosis
Serum Amyloid P-Component
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Summary:Amyloid associated with seven sclerotic and two normal aortic and mitral valves was studied. The sclerotic valve amyloid contained microfibrils with typical random orientation and a fibril width of 9.5-12.5 nm. The amyloid deposits demonstrated permanganate-resistant Congophilia and contained the amino acid tryptophan. Immunofluorescence studies showed P-component in amyloid deposits of 6 of 7 valves, but none of the sclerotic valves contained amyloid fibril proteins of the AL (primary), AA (secondary), AEt (medullary thyroid carcinoma) or ASc1 (senile cardiac) types. Two non-sclerotic valves, removed from a patient with systemic amyloidosis, showed permanganate-sensitive Congophilic amyloid deposits which contained amyloid fibril protein AA.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.36.12.1342