Disseminated toxoplasmosis in cardiac transplantation

The first case of disseminated toxoplasmosis following cardiac transplantation in the UK is described, with details of Toxoplasma antibody tests made on other cardiac transplant patients. Sixteen of 40 (39%) of recipients had Toxoplasma antibody before operation. Eleven of 30 (37%) of donors had Tox...

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Bibliographic Details
Published in:Journal of clinical pathology 1984-01, Vol.37 (1), p.74-77
Main Authors: McGregor, C G, Fleck, D G, Nagington, J, Stovin, P G, Cory-Pearce, R, English, T A
Format: Article
Language:English
Subjects:
Adult
Antibodies - analysis
Biological and medical sciences
Heart - microbiology
Heart Transplantation
Humans
Immunosuppression
Male
Medical sciences
Myocardium - pathology
Postoperative Complications
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Toxoplasma - immunology
Toxoplasma - isolation & purification
Toxoplasmosis - transmission
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Description
Summary:The first case of disseminated toxoplasmosis following cardiac transplantation in the UK is described, with details of Toxoplasma antibody tests made on other cardiac transplant patients. Sixteen of 40 (39%) of recipients had Toxoplasma antibody before operation. Eleven of 30 (37%) of donors had Toxoplasma antibody. The were four occasions when a negative recipient received a heart from a positive donor. Three survived the immediate postoperative period and two became infected with toxoplasmosis. The implications of this are discussed. Disseminated toxoplasmosis appears much more often when heart muscle from a dye test positive donor is given to a dye test negative recipient. Antibiotic therapy is limited by the fact that the antitoxoplasma drugs available are static in their effect, and need to be given for prolonged periods postoperatively.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.37.1.74