ATG7 promotes the tumorigenesis of lung cancer but might be dispensable for prognosis predication: a clinicopathologic study

Lung cancer is the most frequent cause of cancer-related death worldwide. Dysregulated autophagy is often observed in lung cancer. Autophagy-related 7 (ATG7) is an autophagy gene that is essential for the biogenesis of autophagosomes. Although ATG7-deficient mouse models have demonstrated that ATG7-...

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Bibliographic Details
Published in:OncoTargets and therapy 2016-01, Vol.9, p.4975-4981
Main Authors: Sun, Shaoxing, Wang, Zhihao, Tang, Fang, Hu, Pengchao, Yang, Zetian, Xue, Chao, Gong, Jun, Shi, Liu, Xie, Conghua
Format: Article
Language:English
Subjects:
Autophagy
Autophagy (Cytology)
Cancer therapies
Care and treatment
Chemotherapy
Development and progression
Gene expression
Genetic aspects
Health aspects
Homeostasis
Hospitals
Kinases
Lung cancer
Mammals
Medical prognosis
Metabolism
Oncogenes
Original Research
Pathology
Prognosis
Proteins
Radiation therapy
Surgery
Tumorigenesis
Tumors
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Summary:Lung cancer is the most frequent cause of cancer-related death worldwide. Dysregulated autophagy is often observed in lung cancer. Autophagy-related 7 (ATG7) is an autophagy gene that is essential for the biogenesis of autophagosomes. Although ATG7-deficient mouse models have demonstrated that ATG7-dependent autophagy is required for lung cancer tumorigenesis, the relationship between ATG7 expression levels and human lung cancer is unclear. Here, we demonstrate that ATG7 was overexpressed in human lung cancer tissues compared with normal tissues. However, ATG7 expression was not associated with tumor differentiation, tumor size, or TNM stage. Moreover, the overexpression of ATG7 did not influence the overall survival of the lung cancer patients. Therefore, our results indicate that ATG7 might be dispensable for tumor growth and chemotherapy efficacy in human lung cancer.
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S107876