SAbPred: a structure-based antibody prediction server

SAbPred is a server that makes predictions of the properties of antibodies focusing on their structures. Antibody informatics tools can help improve our understanding of immune responses to disease and aid in the design and engineering of therapeutic molecules. SAbPred is a single platform containin...

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Bibliographic Details
Published in:Nucleic acids research 2016-07, Vol.44 (W1), p.W474-W478
Main Authors: Dunbar, James, Krawczyk, Konrad, Leem, Jinwoo, Marks, Claire, Nowak, Jaroslaw, Regep, Cristian, Georges, Guy, Kelm, Sebastian, Popovic, Bojana, Deane, Charlotte M
Format: Article
Language:English
Subjects:
Algorithms
Antibodies - chemistry
Antibodies - immunology
Antigens - chemistry
Antigens - immunology
Binding Sites, Antibody - immunology
Epitopes - chemistry
Epitopes - immunology
Immunoglobulin Variable Region - chemistry
Immunoglobulin Variable Region - immunology
Internet
Models, Molecular
Molecular Sequence Annotation
Software
User-Computer Interface
Web Server issue
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Summary:SAbPred is a server that makes predictions of the properties of antibodies focusing on their structures. Antibody informatics tools can help improve our understanding of immune responses to disease and aid in the design and engineering of therapeutic molecules. SAbPred is a single platform containing multiple applications which can: number and align sequences; automatically generate antibody variable fragment homology models; annotate such models with estimated accuracy alongside sequence and structural properties including potential developability issues; predict paratope residues; and predict epitope patches on protein antigens. The server is available at http://opig.stats.ox.ac.uk/webapps/sabpred.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkw361