Rapid processing of fetal skin for prenatal diagnosis by light and electron microscopy

A method has been developed for rapid processing of fetal skin for prenatal diagnosis of hereditary skin diseases by light and electron microscopy. Fixation, dehydration, embedding, and polymerisation can be achieved in about 5 h. The quality of tissue preservation compares favourably with that prod...

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Bibliographic Details
Published in:Journal of clinical pathology 1984-06, Vol.37 (6), p.633-638
Main Authors: Eady, R A, Gunner, D B, Tidman, M J, Nicolaides, K H, Rodeck, C H
Format: Article
Language:English
Subjects:
Biological and medical sciences
Dermatology
Female
Fetal Diseases - diagnosis
Fetal Diseases - pathology
Fetoscopy
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Microscopy
Microscopy, Electron
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Pregnancy
Pregnancy Trimester, Second
Prenatal Diagnosis - methods
Skin - pathology
Skin Diseases - diagnosis
Skin Diseases - genetics
Skin Diseases - pathology
Time Factors
Tissue Preservation - methods
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Summary:A method has been developed for rapid processing of fetal skin for prenatal diagnosis of hereditary skin diseases by light and electron microscopy. Fixation, dehydration, embedding, and polymerisation can be achieved in about 5 h. The quality of tissue preservation compares favourably with that produced by slower conventional techniques. This procedure may provoke a wider interest in the potential use of fetal skin biopsy in prenatal diagnosis, especially if identification of structural abnormalities is a feasible alternative to more time consuming biochemical analysis.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.37.6.633