Antibacterial coating on biocomposites for cranio-facial reconstruction

• Published in: Clujul medical 2016, Vol.89 (3), p.430-434
• Main Authors: Lazar, Madalina Anca, Vodnar, Dan, Prodan, Doina, Rotaru, Horatiu, Roman, Calin Rares, Sorcoi, Lidia Adriana, Baciut, Grigore, Campian, Radu Septimiu
• Format: Article
• Language: English
• Subjects: Original Research
• ISSN: 2602-0807; 1222-2119; 2668-0572; 2066-8872
• DOI: 10.15386/cjmed-599

Background and aims. Despite the fact that implants are sterilized, antiseptic techniques are applied and systemic antibiotics are routinely administered prior to and after craniofacial surgery, infection rates between 3% and 40% are still reported for alloplastic implants, urging for implant removal. The present study focuses on the development of a fiber-reinforced composite (FRC) implant for craniofacial reconstruction with antimicrobial properties.Methods. A new fiber-reinforced composite coated with gentamicin was developed and tested for bacterial adherence and antibacterial efficiency, using two of the most involved bacterial strains in the postoperative infections: Staphylococcus aureus and Pseudomonas aeruginosa.Results. Bacteria were efficiently inactivated in direct contact with gentamicin coatings (p0.05 and Pseudomonas aeruginosa: β = -0.921; p=0.255>0.05), a negative relation was observed, indicating the reversed relation between the antibiotic dosage and the bacterial adherence.Conclusion. The results of the two applied microbiological protocols used in the study suggested that gentamicin eluting coating inhibited not only the bacterial growth, but also led to a lower initial bacterial adhesion to the surface of the implant. Thus, antibiotic coating of craniofacial implants may reduce the infection rate related to reconstructive surgery.