Control of rapid nitric acid decalcification

Decalcification is commonly employed in most histopathology laboratories for the microscopical examination of bone and other calcified tissues. Many alternative decalcification regimens have been proposed, but most of them have some unsatisfactory characteristics. In an attempt to reduce the commonl...

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Bibliographic Details
Published in:Journal of clinical pathology 1984-12, Vol.37 (12), p.1409-1413
Main Authors: Mawhinney, W H, Richardson, E, Malcolm, A J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bone and Bones - anatomy & histology
Bones, joints and connective tissue. Antiinflammatory agents
Decalcification Technique
Humans
Medical sciences
Nitrates
Nitric Acid
Organ Size
Pharmacology. Drug treatments
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Summary:Decalcification is commonly employed in most histopathology laboratories for the microscopical examination of bone and other calcified tissues. Many alternative decalcification regimens have been proposed, but most of them have some unsatisfactory characteristics. In an attempt to reduce the commonly encountered artfacts of tissue shrinkage and adverse staining results obtained with rapid decalcification in strong mineral acids such as nitric acid many labortories have utilised the much slower decalcification achieved with formic acid or EDTA.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.37.12.1409