Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury

Plasma-circulating microRNAs have been implicated as novel early biomarkers for myocardial infarction (MI) due to their high specificity for cardiac injury. For swift clinical translation of this potential biomarker, it is important to understand their temporal and spatial characteristics upon MI. T...

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Bibliographic Details
Published in:Journal of cardiovascular translational research 2016-08, Vol.9 (4), p.291-301
Main Authors: Deddens, Janine C., Vrijsen, Krijn R., Colijn, Johanna M., Oerlemans, Martinus I., Metz, Corina H. G., van der Vlist, Els J., Nolte-’t Hoen, Esther N. M., den Ouden, Krista, Jansen Of Lorkeers, Sanne J., van der Spoel, Tycho I. G., Koudstaal, Stefan, Arkesteijn, Ger J., Wauben, Marca H. M., van Laake, Linda W., Doevendans, Pieter A., Chamuleau, Steven A. J., Sluijter, Joost P. G.
Format: Article
Language:English
Subjects:
Animals
Biomedical Engineering and Bioengineering
Biomedicine
Cardiology
Disease Models, Animal
Extracellular Vesicles - metabolism
Female
Genetic Markers
Human Genetics
Isolated Heart Preparation
Male
Medicine
Medicine & Public Health
Mice, Inbred C57BL
MicroRNAs - blood
MicroRNAs - genetics
Myocardial Infarction - blood
Myocardial Infarction - diagnosis
Myocardial Infarction - genetics
Myocardial Reperfusion Injury - blood
Myocardial Reperfusion Injury - diagnosis
Myocardial Reperfusion Injury - genetics
Original
Original Article
Sus scrofa
Time Factors
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Summary:Plasma-circulating microRNAs have been implicated as novel early biomarkers for myocardial infarction (MI) due to their high specificity for cardiac injury. For swift clinical translation of this potential biomarker, it is important to understand their temporal and spatial characteristics upon MI. Therefore, we studied the temporal release, potential source, and transportation of circulating miRNAs in different models of ischemia reperfusion (I/R) injury. We demonstrated that extracellular vesicles are released from the ischemic myocardium upon I/R injury. Moreover, we provided evidence that cardiac and muscle-specific miRNAs are transported by extracellular vesicles and are rapidly detectable in plasma. Since these vesicles are enriched for the released miRNAs and their detection precedes traditional damage markers, they hold great potential as specific early biomarkers for MI.
ISSN:1937-5387
1937-5395
DOI:10.1007/s12265-016-9705-1