The role of N-glycans in colorectal cancer progression: potential biomarkers and therapeutic applications

Changes in glycosylation, which is one of the most common protein post-translational modifications, are considered to be a hallmark of cancer. N-glycans can modulate cell migration, cell-cell adhesion, cell signaling, growth and metastasis. The colorectal cancer (CRC) is a leading cause of cancer-re...

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Bibliographic Details
Published in:Oncotarget 2016-04, Vol.7 (15), p.19395-19413
Main Authors: de Freitas Junior, Julio Cesar Madureira, Morgado-Díaz, José Andrés
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - therapeutic use
Biomarkers, Tumor - antagonists & inhibitors
Biomarkers, Tumor - metabolism
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Disease Progression
Glycosylation - drug effects
Humans
Models, Biological
N-Acetylglucosaminyltransferases - antagonists & inhibitors
N-Acetylglucosaminyltransferases - metabolism
Polysaccharides - antagonists & inhibitors
Polysaccharides - chemistry
Polysaccharides - metabolism
Review
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Summary:Changes in glycosylation, which is one of the most common protein post-translational modifications, are considered to be a hallmark of cancer. N-glycans can modulate cell migration, cell-cell adhesion, cell signaling, growth and metastasis. The colorectal cancer (CRC) is a leading cause of cancer-related mortality and the correlation between CRC progression and changes in the pattern of expression of N-glycans is being considered in the search for new biomarkers. Here, we review the role of N-glycans in CRC cell biology. The perspectives on emerging N-glycan-related anticancer therapies, along with new insights and challenges, are also discussed.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.6283