Cerebellar EBV-associated diffuse large B cell lymphoma following angioimmunoblastic T cell lymphoma

Epstein-Barr virus (EBV)-associated B cell lymphoproliferative disorders may be seen in patients with angioimmunoblastic T cell lymphoma (AITL). Although both nodal and extranodal sites of involvement have been described, central nervous system involvement by B cell lymphoma following AITL has not p...

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Bibliographic Details
Published in:Journal of hematopathology 2015-12, Vol.8 (4), p.235-241
Main Authors: Zhou, Yi, Rosenblum, Marc K., Dogan, Ahmet, Jungbluth, Achim A., Chiu, April
Format: Article
Language:English
Subjects:
Case Report
Epstein-Barr virus
Hematology
Medicine & Public Health
Pathology
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Summary:Epstein-Barr virus (EBV)-associated B cell lymphoproliferative disorders may be seen in patients with angioimmunoblastic T cell lymphoma (AITL). Although both nodal and extranodal sites of involvement have been described, central nervous system involvement by B cell lymphoma following AITL has not previously been documented. We report a first example of such unusual presentation, in which an 80-year-old man developed diffuse large B cell lymphoma (DLBCL) in the cerebellum 4 months after the initial diagnosis of AITL. EBV-encoded RNAs were detected in the DLBCL, suggesting that EBV played a pivotal role in the pathogenesis of high-grade histologic progression of AITL. The patient survived less than 9 months after his initial diagnosis of AITL. We believe that this case expands the spectrum of extranodal manifestation of EBV-positive B cell lymphoma associated with AITL and illustrates the importance of recognition of this association when encountering unusual central nervous system lesions in patients with known AITL.
ISSN:1868-9256
1865-5785
DOI:10.1007/s12308-015-0241-8