Prevalence and factors associated with nontuberculous mycobacteria in non-cystic fibrosis bronchiectasis: a multicenter observational study

Data on the prevalence of and factors associated with nontuberculous mycobacteria (NTM) in patients with non-cystic fibrosis (CF) bronchiectasis are limited. Our aim was to determine the prevalence and factors associated with isolation of NTM in this population. We performed a multicenter observatio...

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Bibliographic Details
Published in:BMC infectious diseases 2016-08, Vol.16 (1), p.437-437, Article 437
Main Authors: Máiz, L, Girón, R, Olveira, C, Vendrell, M, Nieto, R, Martínez-García, M A
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Analysis
Body Mass Index
Bronchiectasis
Bronchiectasis - complications
Bronchiectasis - diagnostic imaging
Complications and side effects
Cystic Fibrosis - complications
Epidemiology
Female
Fibrosis
Humans
Infectious diseases
Male
Middle Aged
Mycobacterium avium
Mycobacterium avium Complex - isolation & purification
Mycobacterium Infections, Nontuberculous - complications
Mycobacterium Infections, Nontuberculous - diagnosis
Mycobacterium Infections, Nontuberculous - microbiology
Nontuberculous Mycobacteria - isolation & purification
Odds Ratio
Prevalence
Risk factors
Sputum - microbiology
Tomography, X-Ray Computed
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Summary:Data on the prevalence of and factors associated with nontuberculous mycobacteria (NTM) in patients with non-cystic fibrosis (CF) bronchiectasis are limited. Our aim was to determine the prevalence and factors associated with isolation of NTM in this population. We performed a multicenter observational study of historical cohorts comprising consecutive patients with non-CF bronchiectasis and at least 2 sputum samples cultured for mycobacteria over a period of 5 years. The study population included 218 adult patients (61.9 % women) with a mean (SD) age of 55.7 (16) years and a mean (SD) of 5.1 (3.3) cultures/patient. NTM was isolated from sputum in 18 patients (8.3 %). Of these, 5 patients (28 %) met the American Thoracic Society criteria for NTM disease. Mycobacterium avium complex was the most frequently isolated microorganism (9 patients, 4.1 %). The variables independently associated with isolation of NTM were FVC ≥ 75 % predicted (OR, 4.84; 95 % CI 1.47 to 15.9; p 
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-016-1774-x