Docosahexaenoic Acid Rescues Synaptogenesis Impairment and Long-Term Memory Deficits Caused by Postnatal Multiple Sevoflurane Exposures

Sevoflurane exposures were demonstrated to induce neurotoxicity in the developing brain in both human and animal studies. However, there is no effective approach to reverse it. The present study aimed to evaluate the feasibility of utilizing docosahexaenoic acid (DHA) to prevent sevoflurane-induced...

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Bibliographic Details
Published in:BioMed research international 2016-01, Vol.2016 (2016), p.1-7
Main Authors: Yu, Buwei, Tan, Yongchang, Li, Guohui, Xue, Qingsheng, Luo, Yan, Tao, Guorong, Xiao, Jinglei
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesiology
Anesthetics
Anesthetics, Inhalation - adverse effects
Animal memory
Animals
Animals, Newborn
Biomedical research
Docosahexaenoic Acids - administration & dosage
Drug Interactions
Female
Laboratory animals
Male
Medical research
Membranes
Memory Disorders - chemically induced
Memory Disorders - prevention & control
Memory, Long-Term - drug effects
Methyl Ethers - adverse effects
Mice
Mice, Inbred C57BL
Microscopy
Neurogenesis - drug effects
Neurotoxicity
Omega-3 fatty acids
Rodents
Sevoflurane
Studies
Synapses - drug effects
Treatment Outcome
Unsaturated fatty acids
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Summary:Sevoflurane exposures were demonstrated to induce neurotoxicity in the developing brain in both human and animal studies. However, there is no effective approach to reverse it. The present study aimed to evaluate the feasibility of utilizing docosahexaenoic acid (DHA) to prevent sevoflurane-induced neurotoxicity. P6 (postnatal 6 days) mice were administrated DHA after exposure to 3% sevoflurane for two hours daily in three consecutive days. Molecular expressions of synaptic makers (PSD95, synaptophysin) and synaptic morphological changes were investigated by Western blot analysis and transmission electron microscopy, respectively. Meanwhile, Morris water maze test was used to assess spatial memory of mice at P31 (postnatal 31 days). DHA restored sevoflurane-induced decreased level of PSD95 and synaptophysin expressions and increased PSD areas and also improved long-term spatial memory. These results suggest that DHA could rescue synaptogenesis impairment and long-term memory deficits in postnatal caused by multiple sevoflurane exposures.
ISSN:2314-6133
2314-6141
DOI:10.1155/2016/4062579