Oxidized (non)-regenerated cellulose affects fundamental cellular processes of wound healing

In this study we investigated how hemostats such as oxidized regenerated cellulose (ORC, TABOTAMP) and oxidized non-regenerated cellulose (ONRC, RESORBA CELL) influence local cellular behavior and contraction of the extracellular matrix (ECM). Human stromal fibroblasts were inoculated in vitro with...

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Bibliographic Details
Published in:Scientific reports 2016-08, Vol.6 (1), p.32238-32238, Article 32238
Main Authors: Wagenhäuser, M. U., Mulorz, J., Ibing, W., Simon, F., Spin, J. M., Schelzig, H., Oberhuber, A.
Format: Article
Language:English
Subjects:
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Cell growth
Cell proliferation
Cellulose
Collagen
Extracellular matrix
Fibroblasts
Gels
Humanities and Social Sciences
multidisciplinary
pH effects
Science
Wound healing
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Summary:In this study we investigated how hemostats such as oxidized regenerated cellulose (ORC, TABOTAMP) and oxidized non-regenerated cellulose (ONRC, RESORBA CELL) influence local cellular behavior and contraction of the extracellular matrix (ECM). Human stromal fibroblasts were inoculated in vitro with ORC and ONRC. Cell proliferation was assayed over time and migration was evaluated by Live Cell imaging microscopy. Fibroblasts grown in collagen-gels were treated with ORC or ONRC and ECM contraction was measured utilizing a contraction assay. An absolute pH decline was observed with both ORC and ONRC after 1 hour. Mean daily cell proliferation, migration and matrix contraction were more strongly inhibited by ONRC when compared with ORC (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/srep32238