Association of C677T MTHFR and G20210A FII prothrombin polymorphisms with susceptibility to myocardial infarction

Myocardial infarction (MI) is a common complex pathology, localized in the main leading causes of mortality worldwide. It is the result of the interaction of genetic and environmental factors. The aim of the present study was to investigate the potential association of C677T 5,10-methylenetetrahydro...

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Bibliographic Details
Published in:Biomedical reports 2016-09, Vol.5 (3), p.361-366
Main Authors: Hmimech, Wiam, Idrissi, Hind Hassani, Diakite, Brehima, Baghdadi, Dalila, Korchi, Farah, Habbal, Rachida, Nadifi, Sellama
Format: Article
Language:English
Subjects:
Age
association
Binding sites
C677T MTHFR
Confidence intervals
Deoxyribonucleic acid
Diabetes
Disease control
DNA
DNA methylation
Environmental factors
Enzymes
G20210A FII
Gene polymorphism
Genes
Genetic aspects
Genetic markers
Genetic testing
Heart attack
Heart attacks
Heterozygotes
Homocysteine
Hypertension
Methylenetetrahydrofolate reductase
Moroccan population
Mortality
Mutation
Myocardial infarction
Patients
Polymerase chain reaction
Polymorphism
Prothrombin
Restriction fragment length polymorphism
Salting
susceptibility
Thrombin
Thrombosis
Vitamin B
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Summary:Myocardial infarction (MI) is a common complex pathology, localized in the main leading causes of mortality worldwide. It is the result of the interaction of genetic and environmental factors. The aim of the present study was to investigate the potential association of C677T 5,10-methylenetetrahydrofolate reductase (MTHFR) (rs1801133) and G20210A factor II prothrombin (FII) (rs1799963) polymorphisms with the susceptibility of MI. Following extraction by the standard salting-out procedure, DNA samples of 100 MI patients and 182 apparently healthy controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism using HinfI and HindIII restriction enzymes, respectively. The results show a significant association of the G20210T FII polymorphism with the MI risk. The frequencies of the heterozygote genotype GA, homozygous mutated AA and the G20210A allele was higher among patients compared to controls (GA: 59 vs. 5.5%, P
ISSN:2049-9434
2049-9442
DOI:10.3892/br.2016.717