Potential role of bromelain in clinical and therapeutic applications

Pineapple has been used as part of traditional folk medicine since ancient times and it continues to be present in various herbal preparations. Bromelain is a complex mixture of protease extracted from the fruit or stem of the pineapple plant. Although the complete molecular mechanism of action of b...

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Bibliographic Details
Published in:Biomedical reports 2016-09, Vol.5 (3), p.283-288
Main Authors: Rathnavelu, Vidhya, Alitheen, Noorjahan Banu, Sohila, Subramaniam, Kanagesan, Samikannu, Ramesh, Rajendran
Format: Article
Language:English
Subjects:
Angiogenesis
anti-microbial
anticancer
Anticancer properties
Antitumor activity
Apoptosis
Bromelain
Cancer therapies
Cancer treatment
Cell cycle
Fibrin
Health aspects
Herbal medicine
Immune system
Immunomodulation
Inflammation
Ischemia
Metastasis
pineapple
Plant extracts
Reagents
Review
Rheumatoid arthritis
Side effects
Studies
Therapeutic applications
therapeutics
Tumor necrosis factor-TNF
Wound healing
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Summary:Pineapple has been used as part of traditional folk medicine since ancient times and it continues to be present in various herbal preparations. Bromelain is a complex mixture of protease extracted from the fruit or stem of the pineapple plant. Although the complete molecular mechanism of action of bromelain has not been completely identified, bromelain gained universal acceptability as a phytotherapeutic agent due to its history of safe use and lack of side effects. Bromelain is widely administered for its well-recognized properties, such as its anti-inflammatory, antithrombotic and fibrinolytic affects, anticancer activity and immunomodulatory effects, in addition to being a wound healing and circulatory improvement agent. The current review describes the promising clinical applications and therapeutic properties of bromelain.
ISSN:2049-9434
2049-9442
DOI:10.3892/br.2016.720