Prevalence of Human Papillomavirus Genotypes Among Women With High-Grade Cervical Lesions in Beijing, China

The aim of the study is to investigate the prevalence of high-risk human papillomavirus (hr-HPV) genotypes among Han women with high-grade cervical lesions in Beijing, China.Cervical cell specimens from patients with histopathologically confirmed cervical lesions at 7 hospitals in Beijing were exami...

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Bibliographic Details
Published in:Medicine (Baltimore) 2016-01, Vol.95 (3), p.e2555-e2555
Main Authors: Xiao, Meizhu, Xu, Qiuxiang, Li, Hongyan, Gao, Huiqiao, Bie, Yachun, Zhang, Zhenyu
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Adenocarcinoma - virology
Adult
Aged
Cervical Intraepithelial Neoplasia - pathology
Cervical Intraepithelial Neoplasia - virology
Cervix Uteri - pathology
Cervix Uteri - virology
China - epidemiology
Female
Genotype
Human papillomavirus 16 - genetics
Human papillomavirus 18 - genetics
Humans
Middle Aged
Neoplasms, Squamous Cell - pathology
Neoplasms, Squamous Cell - virology
Observational Study
Papillomaviridae - genetics
Papillomavirus Infections - pathology
Papillomavirus Infections - virology
Prevalence
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - virology
Young Adult
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Summary:The aim of the study is to investigate the prevalence of high-risk human papillomavirus (hr-HPV) genotypes among Han women with high-grade cervical lesions in Beijing, China.Cervical cell specimens from patients with histopathologically confirmed cervical lesions at 7 hospitals in Beijing were examined with a validated HPV kit for 13 hr-HPV genotypes during the study period. The patients were divided into a low-grade cervical lesions group (cervical intraepithelial neoplasia grade 1, CIN1) and a high-grade cervical lesions group (CIN2+, including cervical intraepithelial neoplasia grade 2, CIN2; cervical intraepithelial neoplasia grade 3, CIN3; squamous cervical cancer, SCC; and adenocarcinoma of the cervix, ACC) based on the histopathology results.A total of 2817 eligible patients were enrolled, including 610 cases identified as CIN1 and 2207 as CIN2+. The hr-HPV positive rates in the CIN1 and CIN2+ groups were 78.2% (477/610) and 93.3% (2060/2207), respectively. The most frequently detected genotypes were HPV16, 58, 52 and18 in the CIN1 group and HPV16, 58, 33, and 52 in the CIN2+ group, in descending order of prevalence. In addition, the prevalence of HPV18 among the patients with ACC was 28.6% (14/49), significantly >7.2% (54/752) prevalence among the SCC patients (P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000002555