Impact of Age on the Prognosis of Operable Gastric Cancer Patients: An Analysis Based on SEER Database

To investigate the impact of age on the clinicopathological features and survival of patients with gastric cancer (GC), and hope to better define age-specific patterns of GC and possible associated risk factors.Using the surveillance, epidemiology, and end results (SEER) database to search the patie...

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Bibliographic Details
Published in:Medicine (Baltimore) 2016-06, Vol.95 (24), p.e3944-e3944
Main Authors: Chen, Jie, Chen, Jinggui, Xu, Yu, Long, Ziwen, Zhou, Ye, Zhu, Huiyan, Wang, Yanong, Shi, Yingqiang
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Biopsy
China - epidemiology
Female
Hepatectomy
Humans
Liver - pathology
Male
Middle Aged
Observational Study
Prognosis
Proportional Hazards Models
Risk Assessment - methods
Risk Factors
SEER Program
Stomach Neoplasms - diagnosis
Stomach Neoplasms - mortality
Stomach Neoplasms - surgery
Survival Rate - trends
Young Adult
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Summary:To investigate the impact of age on the clinicopathological features and survival of patients with gastric cancer (GC), and hope to better define age-specific patterns of GC and possible associated risk factors.Using the surveillance, epidemiology, and end results (SEER) database to search the patients who diagnosed GC between 2007 and 2011 with a known age. The overall and 5-year gastric cancer specific survival (CSS) data were obtained using Kaplan-Meier plots. Multivariable Cox regression models were built for the analysis of long-term survival outcomes and risk factors.A total of 7762 GC patients treated with surgery during the 4-year study period were included in the final study cohort. We divided into five subgroups according to the different age ranges. The overall 5-year cause-specific survival (CSS) was 60.3% in Group 1 (below 45 years), 60.3% in the Group 2 (45-55 years), 61.2% in Group 3 (56-65 years), 59.2% in Group 4 (66-75 years), and 59.2% in Group 5 (older than 76 years). Kaplan-Meier plots showed that patients older than 76 years had the worst 5-year CSS of 56.0% rate in all the subgroups. Age, tumor size, primary site, histological type, and Tumor Node Metastasis stage were identified as significant risk factors for poor survival on univariate analysis (all P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000003944