Genetic Variation in the Human SORBS1 Gene is Associated With Blood Pressure Regulation and Age at Onset of Hypertension: A SAPPHIRe Cohort Study

Essential hypertension is a complex disease involving multiple genetic and environmental factors. A human gene containing a sorbin homology domain and 3 SH3 domains in the C-terminal region, termed SORBS1, plays a significant role in insulin signaling. We previously found a significant association b...

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Published in:Medicine (Baltimore) 2016-03, Vol.95 (10), p.e2970-e2970
Main Authors: Chang, Tien-Jyun, Wang, Wen-Chang, Hsiung, Chao A., He, Chih-Tsueng, Lin, Ming-Wei, Sheu, Wayne Huey-Herng, Chang, Yi-Cheng, Quertermous, Tom, Chen, Ida, Rotter, Jerome, Chuang, Lee-Ming
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Blood Pressure - genetics
Cohort Studies
Diastole
Female
Genotype
Humans
Hypertension - epidemiology
Hypertension - genetics
Male
Microfilament Proteins - genetics
Middle Aged
Observational Study
Polymorphism, Single Nucleotide
Prevalence
Systole
Taiwan - epidemiology
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Summary:Essential hypertension is a complex disease involving multiple genetic and environmental factors. A human gene containing a sorbin homology domain and 3 SH3 domains in the C-terminal region, termed SORBS1, plays a significant role in insulin signaling. We previously found a significant association between the T228A polymorphism and insulin resistance, obesity, and type 2 diabetes. It has been hypothesized that a set of genes responsible for insulin resistance may be closely linked with genes susceptible to the development of hypertension. Identification of insulin resistance-related genetic factors may, therefore, enhance our understanding of essential hypertension. This study aimed to examine whether common SORBS1 genetic variations are associated with blood pressure and age at onset of hypertension in an ethnic Chinese cohort.We genotyped 9 common tagged single nucleotide polymorphisms of the SORBS1 gene in 1136 subjects of Chinese origin from the Stanford Asia-Pacific Program for Hypertension and Insulin Resistance family study. Blood pressure was measured upon enrolment. The associations of the SORBS1 single nucleotide polymorphisms with blood pressure and the presence of hypertension were analyzed with a generalized estimating equation model. We used the false-discovery rate measure Q value with a cutoff
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000002970