Expression kinetics of hepatic progenitor markers in cellular models of human liver development recapitulating hepatocyte and biliary cell fate commitment

Due to the limitations of research using human embryos and the lack of a biological model of human liver development, the roles of the various markers associated with liver stem or progenitor cell potential in humans are largely speculative, and based on studies utilizing animal models and certain p...

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Bibliographic Details
Published in:Experimental biology and medicine (Maywood, N.J.) N.J.), 2016-09, Vol.241 (15), p.1653-1662
Main Authors: Chaudhari, Pooja, Tian, Lipeng, Deshmukh, Abhijeet, Jang, Yoon-Young
Format: Article
Language:English
Subjects:
Animals
Biliary Tract - cytology
Biliary Tract - growth & development
Biomarkers
Cell & Developmental Biology
Cell Differentiation - physiology
Hepatocytes - physiology
Humans
Liver - cytology
Liver - growth & development
Stem Cells - physiology
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Summary:Due to the limitations of research using human embryos and the lack of a biological model of human liver development, the roles of the various markers associated with liver stem or progenitor cell potential in humans are largely speculative, and based on studies utilizing animal models and certain patient tissues. Human pluripotent stem cell-based in vitro multistage hepatic differentiation systems may serve as good surrogate models for mimicking normal human liver development, pathogenesis and injury/regeneration studies. Here, we describe the implications of various liver stem or progenitor cell markers and their bipotency (i.e. hepatocytic- and biliary-epithelial cell differentiation), based on the pluripotent stem cell-derived model of human liver development. Future studies using the human cellular model(s) of liver and biliary development will provide more human relevant biological and/or pathological roles of distinct markers expressed in heterogeneous liver stem/progenitor cell populations.
ISSN:1535-3702
1535-3699
DOI:10.1177/1535370216657901