KIAA0319 gene polymorphisms are associated with developmental dyslexia in Chinese Uyghur children

The gene KIAA0319 has been reported to be associated with developmental dyslexia (DD) in previous studies, although the results have not always been consistent. However, few studies have been conducted in Uyghur populations. In the present study, we aimed to investigate the association of KIAA0319 p...

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Bibliographic Details
Published in:Journal of human genetics 2016-08, Vol.61 (8), p.745-752
Main Authors: Zhao, Hua, Chen, Yun, Zhang, Bao-Ping, Zuo, Peng-Xiang
Format: Article
Language:English
Subjects:
Alleles
Asian Continental Ancestry Group - genetics
Case-Control Studies
Child
China
Dyslexia - genetics
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Male
Nerve Tissue Proteins - genetics
Original
Polymorphism, Single Nucleotide
Risk Factors
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Summary:The gene KIAA0319 has been reported to be associated with developmental dyslexia (DD) in previous studies, although the results have not always been consistent. However, few studies have been conducted in Uyghur populations. In the present study, we aimed to investigate the association of KIAA0319 polymorphisms and DD in individuals of Uyghurian descent. We used a custom-by-design 48-Plex SNPscan Kit to genotype 18 single-nucleotide polymorphisms (SNPs) of KIAA0319 in a group of 196 children with dyslexia and 196 controls of Uyghur descent aged 8-12 years. As a result, 7 SNPs (Pmin=0.001) of KIAA0319 had nominal significant differences between the cases and controls under specific genotypic models. The two SNPs rs6935076 (P=0.020 under dominant model; P=0.028 under additive model) and rs3756821 (P=0.021 under additive model) remained significantly associated with dyslexia after Bonferroni correction. Linkage disequilibrium analysis showed three blocks within KIAA0319, and only a 10-SNP haplotype in block 3 was present at significantly different frequencies in the dyslexic children and controls. This study indicated that genetic polymorphisms of KIAA0319 are associated with an increased risk of DD in the Uyghur population.
ISSN:1434-5161
1435-232X
DOI:10.1038/jhg.2016.40