Autoimmunity in chronic lymphocytic leukaemia

The prevalence of autoantibodies in B cell chronic lymphocytic leukaemia (B-CLL) was investigated. A lower prevalence of autoimmune haemolytic anaemia than that found in other series was found: large numbers of non-progressive stage A disease cases were included, in which the prevalence of autoimmun...

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Bibliographic Details
Published in:Journal of clinical pathology 1986-07, Vol.39 (7), p.713-716
Main Authors: Hamblin, T J, Oscier, D G, Young, B J
Format: Article
Language:English
Subjects:
Aged
Anemia, Hemolytic, Autoimmune - complications
Autoantibodies - analysis
B-Lymphocytes - immunology
Biological and medical sciences
Coombs Test
Female
Hematologic and hematopoietic diseases
Humans
Leukemia, Lymphoid - complications
Leukemia, Lymphoid - immunology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Thrombocytopenia - complications
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Description
Summary:The prevalence of autoantibodies in B cell chronic lymphocytic leukaemia (B-CLL) was investigated. A lower prevalence of autoimmune haemolytic anaemia than that found in other series was found: large numbers of non-progressive stage A disease cases were included, in which the prevalence of autoimmune haemolytic anaemia is low. Non-haematological autoantibodies were no commoner than in age matched controls. Whatever explanation is offered for autoimmune phenomena in B-CLL it must take account of the fact that those phenomena are virtually confined to autoantibodies against the formed elements of the blood.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.39.7.713