Systemic reactive amyloidosis associated with Castleman's disease: serial changes of the concentrations of acute phase serum amyloid A and interleukin 6 in serum

A case is reported of a 21 year old woman who suffered from Castleman's disease and systemic reactive amyloidosis. The serum concentrations of serum amyloid A (SAA) and interleukin 6 (IL-6) were extremely high and amyloid protein was immunohistochemically identified as AA. After surgical excisi...

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Bibliographic Details
Published in:Journal of clinical pathology 1997-11, Vol.50 (11), p.965-967
Main Authors: Ikeda, S, Chisuwa, H, Kawasaki, S, Ozawa, J, Hoshii, Y, Yokota, T, Aoi, T
Format: Article
Language:English
Subjects:
Adult
Amyloidosis - blood
Amyloidosis - etiology
Biological and medical sciences
Castleman Disease - blood
Castleman Disease - complications
Castleman Disease - pathology
Female
Hematologic and hematopoietic diseases
Humans
Interleukin-6 - blood
Medical sciences
Other diseases. Hematologic involvement in other diseases
Serum Amyloid A Protein - metabolism
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Summary:A case is reported of a 21 year old woman who suffered from Castleman's disease and systemic reactive amyloidosis. The serum concentrations of serum amyloid A (SAA) and interleukin 6 (IL-6) were extremely high and amyloid protein was immunohistochemically identified as AA. After surgical excision of a large retroperitoneal lymph node with the pathological findings of plasma cell type of Castleman's disease, both serum SAA and IL-6 declined, showing a similar pattern of reduction curves. All clinical symptoms and laboratory abnormalities greatly improved. The biochemical feature of Castleman's disease is abnormal production of IL-6 and this cytokine continuously may stimulate the synthesis of an amyloid precursor, SAA, causing systemic reactive (AA) amyloidosis. This pathogenetic theory is strongly supported by the present study.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.50.11.965