Human Cancers Express a Mutator Phenotype: Hypothesis, Origin, and Consequences

The mutator phenotype hypothesis was postulated more than 40 years ago. It was based on the multiple enzymatic steps required to precisely replicate the 6 billion bases in the human genome each time a normal cell divides. A reduction in this accuracy during tumor progression could be responsible for...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2016-04, Vol.76 (8), p.2057-2059
Main Author: Loeb, Lawrence A
Format: Article
Language:English
Subjects:
Disease Progression
Humans
Mutation
Neoplasms - genetics
Neoplasms - pathology
Phenotype
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Summary:The mutator phenotype hypothesis was postulated more than 40 years ago. It was based on the multiple enzymatic steps required to precisely replicate the 6 billion bases in the human genome each time a normal cell divides. A reduction in this accuracy during tumor progression could be responsible for the striking heterogeneity of malignant cells within a tumor and for the rapidity by which cancers become resistant to therapy. Cancer Res; 76(8); 2057-9. ©2016 AACRSee related article by Loeb et al. Cancer Res. 1974;34:2311-21.
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.can-16-0794