HLA antigen expression in enteropathy associated T cell lymphoma

AIMS: To investigate the occurrence of abnormal patterns of HLA-ABC and HLA-DR expression in enteropathy associated T cell lymphoma and to relate such abnormalities to the Epstein Barr virus (EBV) status of the tumours. METHODS: Eleven enteropathy associated T cell lymphomas were immunostained with...

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Bibliographic Details
Published in:Journal of clinical pathology 1996-07, Vol.49 (7), p.545-548
Main Authors: Ashton-Key, M, Singh, N, Pan, L X, Smith, M E
Format: Article
Language:English
Subjects:
Biological and medical sciences
Hematologic and hematopoietic diseases
Herpesvirus 4, Human - isolation & purification
HLA-A Antigens - isolation & purification
HLA-DR Antigens - isolation & purification
Humans
Immunohistochemistry
Intestinal Neoplasms - immunology
Intestinal Neoplasms - virology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, T-Cell - immunology
Lymphoma, T-Cell - virology
Medical sciences
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Summary:AIMS: To investigate the occurrence of abnormal patterns of HLA-ABC and HLA-DR expression in enteropathy associated T cell lymphoma and to relate such abnormalities to the Epstein Barr virus (EBV) status of the tumours. METHODS: Eleven enteropathy associated T cell lymphomas were immunostained with HC10 (HLA-ABC heavy chain) and TAL 1B5 (HLA-DR alpha chain) monoclonal antibodies and polyclonal anti-beta 2 microglobulin (beta 2m, the HLA-ABC light chain) antibodies. In situ hybridisation for EBV using EBER probes was performed on all cases. RESULTS: Tumour cells of two of 11 patients were EBER positive. One of these showed partial, and the other, complete loss of beta 2m. HLA-DR expression was undetectable in both patients. Of the remaining nine EBER negative tumours, two were HLA-ABC heavy chain negative or showed only occasional positive cells and five of nine showed partial or complete loss of the HLA-ABC light chain, beta 2m. Seven of the nine cases were either negative for HLA-DR or showed weak expression in a proportion of tumour cells. CONCLUSIONS: These data show that low or absent HLA-ABC and HLA-DR antigen expression occurs commonly in enteropathy associated T cell lymphoma. These abnormal patterns of HLA expression may be associated with escape from immune attack which, in a minority of patients, could be directed against EBV antigens.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.49.7.545