Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models

A systems pharmacology model typically integrates pharmacokinetic, biochemical network, and systems biology concepts into a unifying approach. It typically consists of a large number of parameters and reaction species that are interlinked based upon the underlying (patho)physiology and the mechanism...

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Bibliographic Details
Published in:CPT: pharmacometrics and systems pharmacology 2015-02, Vol.4 (2), p.69-79
Main Authors: Zhang, X‐Y, Trame, MN, Lesko, LJ, Schmidt, S
Format: Article
Language:English
Subjects:
Animals
Biology
Humans
Models, Theoretical
Ordinary differential equations
Pharmacokinetics
Pharmacology
Physiology
R&D
Reproducibility of Results
Research & development
Sensitivity analysis
Signal transduction
Systems Biology - methods
Systems Integration
Tutorial
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Summary:A systems pharmacology model typically integrates pharmacokinetic, biochemical network, and systems biology concepts into a unifying approach. It typically consists of a large number of parameters and reaction species that are interlinked based upon the underlying (patho)physiology and the mechanism of drug action. The more complex these models are, the greater the challenge of reliably identifying and estimating respective model parameters. Global sensitivity analysis provides an innovative tool that can meet this challenge. CPT Pharmacometrics Syst. Pharmacol. (2015) 4, 69–79; doi:10.1002/psp4.6; published online 25 February 2015
ISSN:2163-8306
2163-8306
DOI:10.1002/psp4.6