Sepicanin A—A new geranyl flavanone from Artocarpus sepicanus with activity against methicillin-resistant Staphylococcus aureus (MRSA)

Bioassay-guided fractionation of the EtOH extract of Artocarpus sepicanus Diels leaves has led to the isolation of a new geranyl flavanone ( 1), along with the known compounds, afzelechin-3- O-α- l-rhamnopyranoside and β-sitosterol glucoside. The structure of the new compound was established by UV,...

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Bibliographic Details
Published in:Phytochemistry letters 2009-11, Vol.2 (4), p.141-143
Main Authors: Radwan, Mohamed M., Rodriguez-Guzman, Raquel, Manly, Susan P., Jacob, Melissa, Ross, Samir A.
Format: Article
Language:English
Subjects:
Antibacterial
Artocarpus
Artocarpus sepicanus
Flavanone
Methicillin-resistant Staphylococcus aureus
Staphylococcus aureus
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Summary:Bioassay-guided fractionation of the EtOH extract of Artocarpus sepicanus Diels leaves has led to the isolation of a new geranyl flavanone ( 1), along with the known compounds, afzelechin-3- O-α- l-rhamnopyranoside and β-sitosterol glucoside. The structure of the new compound was established by UV, IR, HRESIMS, 1D and 2D NMR experiments. Antimicrobial testing of the three compounds indicated that 1 displayed a significant selective antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) with IC 50 and MIC values of 1.4 and 2.9 μM, respectively.
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2009.04.002