The effect of hyperglycemia on blood coagulation: In vitro, observational healthy-volunteer study using rotational thromboelastometry (ROTEM)

We performed a study to investigate whether contamination of hemostasis samples with a glucose-containing solution might generate spurious results in rotational thromboelastometry (ROTEM) tests.Venous blood was taken from 12 healthy volunteers and divided into 4 specimen bottles, which were contamin...

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Bibliographic Details
Published in:Medicine (Baltimore) 2016-08, Vol.95 (35), p.e4703-e4703
Main Authors: Shin, Hyun-Jung, Na, Hyo-Seok, Lee, Soowon, Lee, Gwan-Woo, Do, Sang-Hwan
Format: Article
Language:English
Subjects:
Adult
Blood Coagulation
Blood Glucose - analysis
Blood Specimen Collection - methods
Fluid Therapy
Glucose - administration & dosage
Humans
In Vitro Techniques
Infusions, Intra-Arterial
Observational Study
Solutions
Thrombelastography - methods
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Summary:We performed a study to investigate whether contamination of hemostasis samples with a glucose-containing solution might generate spurious results in rotational thromboelastometry (ROTEM) tests.Venous blood was taken from 12 healthy volunteers and divided into 4 specimen bottles, which were contaminated with different concentrations (0%, 5%, 10%, and 20%) of glucose solution.Significant lengthening of INTEMCT was observed in the 10% and 20% groups compared with baseline values (7.7% and 9%, P = 0.041 and P = 0.037, respectively). INTEMCFT increased by 20.1% in the 20% group (P = 0.005). INTEMα-angle and INTEMMCF decreased by 3.9% and 2.7%, respectively, in the 20% group (P = 0.010 and P = 0.049, respectively). EXTEMCFT was prolonged significantly, by 10.2%, 15.5%, and 25.6%, in the 5%, 10%, and 20% groups, respectively (P = 0.004, P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000004703