The relationship of the oleic acid level and ECHDC3 mRNA expression with the extent of coronary lesion

The fatty acid profile is associated with the risk and progression of several diseases, probably via mechanisms including its influence on gene expression. We previously reported a correlation between ECHDC3 upregulation and the severity of acute coronary syndrome. Here, we assessed the relationship...

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Published in:Lipids in health and disease 2016-09, Vol.15 (1), p.144-144, Article 144
Main Authors: Duarte, Mychelle Kytchia Rodrigues Nunes, de Araújo, Jéssica Nayara Góes, Duarte, Victor Hugo Rezende, de Oliveira, Katiene Macêdo, de Oliveira, Juliana Marinho, Carioca, Antonio Augusto Ferreira, Bortolin, Raul Hernandes, Rezende, Adriana Augusto, Hirata, Mario Hiroyuki, Hirata, Rosário Domingues, Waitzberg, Dan Linetzky, Lima, Severina Carla Vieira Cunha, Luchessi, André Ducati, Silbiger, Vivian Nogueira
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis
Cardiovascular diseases
Cardiovascular Diseases - genetics
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - pathology
Complications and side effects
Development and progression
Fatty Acids, Monounsaturated - metabolism
Female
Gene expression
Gene Expression Regulation, Enzymologic
Humans
Influence
Male
Messenger RNA
Middle Aged
Myocardium - metabolism
Oleic Acid - genetics
Oleic Acid - metabolism
Peroxisomal Bifunctional Enzyme - biosynthesis
Peroxisomal Bifunctional Enzyme - genetics
Physiology, Pathological
RNA, Messenger - genetics
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Summary:The fatty acid profile is associated with the risk and progression of several diseases, probably via mechanisms including its influence on gene expression. We previously reported a correlation between ECHDC3 upregulation and the severity of acute coronary syndrome. Here, we assessed the relationship of serum fatty acid profile and ECHDC3 expression with the extent of coronary lesion. Fifty-nine individuals aged 30 to 74 years and undergoing elective cinecoronariography for the first time were enrolled in the present study. The extent of coronary lesion was assessed by the Friesinger index and patients were classified as without lesion (n = 18), low lesion (n = 17), intermediate lesion (n = 17) and major lesion (n = 7). Serum biochemistry, fatty acid concentration, and ECHDC3 mRNA expression in blood were evaluated. Elevated serum levels of oleic acid and total monounsaturated fatty acids were observed in patients with low and intermediate lesion, when compared to patients without lesion (p 
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-016-0312-6