One-year Outcomes of Pachymetry and Epithelium Thicknesses after Accelerated (45 mW/cm2) Transepithelial Corneal Collagen Cross-linking for Keratoconus Patients

• Published in: Scientific reports 2016-09, Vol.6 (1), p.32692-32692, Article 32692
• Main Authors: Zhang, Xiaoyu, Sun, Ling, Chen, Yingjun, Li, Meiyan, Tian, Mi, Zhou, Xingtao
• Format: Article
• Language: English
• Subjects: 692/308; 692/308/409; Acuity; Adolescent; Adult; Collagen; Collagen - metabolism; Cornea; Corneal Pachymetry; Cross-linking; Edema; Epithelium; Epithelium, Corneal - pathology; Female; Humanities and Social Sciences; Humans; Keratoconus; Keratoconus - metabolism; Keratoconus - pathology; Keratoconus - surgery; Male; multidisciplinary; Science; Surgery; Tomography, Optical Coherence; Topography; Visual Acuity; Visual Field Tests; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep32692

The thickness of corneal pachymetry and the epithelium after accelerated (45 mW/cm 2 ) transepithelial corneal collagen cross-linking (CXL) for keratoconus were assessed in this prospective case series study. Twenty-eight patients were treated for keratoconus. The mean Kmax was 56.18 ± 7.90. The thinnest point, as assessed by optical coherence tomography (OCT), was 443.18 ± 39.75 μm. Accelerated transepithelial CXL was performed, and corrected distance visual acuity (CDVA), corneal topography, and OCT were recorded at 1 week postoperatively as well as at 1, 3, 6, and 12 months. The surgery was uneventful in all eyes. Postoperative epithelial edema was observed and faded in 3 days. The postoperative Kmax was 54.56 ± 8.81, 55.78 ± 8.11, 56.37 ± 8.71, 55.80 ± 7.92, and 55.47 ± 8.24 at 1 week, 1 month, 3 months, 6 months, and 12 months, respectively (all, P > 0.05). The thinnest postoperative corneal point, 439.04 ± 44.99 μm, was observed at 12 months (P = 0.109). The epithelial thickness decreased during the first postoperative week then showed a gradual recovery. Postoperative pachymetry thickness showed no significant changes for up to 12 months. Postoperative epithelial thickness decreased temporarily, then stabilized at month 12. Accelerated transepithelial CXL was shown to be effective and safe for the treatment of keratoconus.