Apparent Epigenetic Meiotic Double-Strand-Break Disparity in Saccharomyces cerevisiae: A Meta-Analysis

Previously published, and some unpublished, tetrad data from budding yeast (Saccharomyces cerevisiae) are analyzed for disparity in gene conversion, in which one allele is more often favored than the other (conversion disparity). One such disparity, characteristic of a bias in the frequencies of mei...

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Bibliographic Details
Published in:Genetics (Austin) 2016-09, Vol.204 (1), p.129-137
Main Authors: Stahl, Franklin W, Rehan, Maryam Binti Mohamed, Foss, Henriette M, Borts, Rhona H
Format: Article
Language:English
Subjects:
Alcohol Oxidoreductases - genetics
Aminohydrolases - genetics
Argininosuccinate Lyase - genetics
Conversion
DNA Breaks, Double-Stranded
DNA Mismatch Repair
DNA, Fungal - genetics
Epigenesis, Genetic
Epigenetics
Gene Conversion
Genes
Genetic recombination
Investigations
Protocol
Pyrophosphatases - genetics
Recombination, Genetic
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - genetics
Yeast
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Summary:Previously published, and some unpublished, tetrad data from budding yeast (Saccharomyces cerevisiae) are analyzed for disparity in gene conversion, in which one allele is more often favored than the other (conversion disparity). One such disparity, characteristic of a bias in the frequencies of meiotic double-strand DNA breaks at the hotspot near the His4 locus, is found in diploids that undergo meiosis soon after their formation, but not in diploids that have been cloned and frozen. Altered meiotic DNA breakability associated with altered metabolism-related chromatin states has been previously reported. However, the above observations imply that such differing parental chromatin states can persist through at least one chromosome replication, and probably more, in a common environment. This conclusion may have implications for interpreting changes in allele frequencies in populations.
ISSN:1943-2631
0016-6731
1943-2631
DOI:10.1534/genetics.116.191635