Human papillomavirus in squamous cell carcinoma of the oesophagus associated with tylosis

Human papillomavirus (HPV) may have a pathogenic role in squamous cell carcinoma of the oesophagus. Tylosis, an inherited thickening of the skin of the palms and soles, was associated with a high risk of developing squamous cell carcinoma of the oesophagus among members of a large family in Liverpoo...

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Bibliographic Details
Published in:Journal of clinical pathology 1993-06, Vol.46 (6), p.573-575
Main Authors: Ashworth, M T, McDicken, I W, Southern, S A, Nash, J R
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Squamous Cell - complications
Carcinoma, Squamous Cell - microbiology
Esophageal Neoplasms - complications
Esophageal Neoplasms - microbiology
Esophagus
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Keratoderma, Palmoplantar, Diffuse - complications
Male
Medical sciences
Middle Aged
Papillomaviridae
Tumor Virus Infections - complications
Tumors
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Summary:Human papillomavirus (HPV) may have a pathogenic role in squamous cell carcinoma of the oesophagus. Tylosis, an inherited thickening of the skin of the palms and soles, was associated with a high risk of developing squamous cell carcinoma of the oesophagus among members of a large family in Liverpool. The resected carcinomas of the oesophagus was examined from four such patients with DNA probes to HPV types 6,11,16,18,31,33 and 35 using in situ hybridisation under conditions of high stringency. No reaction was detected. The oesophageal biopsy specimens from 10 tylotic subjects without carcinoma were also examined. No HPV DNA was detected. It is concluded that there is no evidence that HPV infection has a role in the development of squamous cell carcinoma of the oesophagus in tylosis.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.46.6.573