Resolving Behavioral Output via Chemogenetic Designer Receptors Exclusively Activated by Designer Drugs

Designer receptors exclusively activated by designer drugs (DREADDs) have proven to be highly effective neuromodulatory tools for the investigation of neural circuits underlying behavioral outputs. They exhibit a number of advantages: they rely on cell-specific manipulations through canonical intrac...

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Bibliographic Details
Published in:The Journal of neuroscience 2016-09, Vol.36 (36), p.9268-9282
Main Authors: Burnett, C Joseph, Krashes, Michael J
Format: Article
Language:English
Subjects:
Animals
Behavior - drug effects
Brain - cytology
Brain - drug effects
Designer Drugs - pharmacology
Drug Design
Humans
Molecular Targeted Therapy
Neurons - drug effects
Receptors, G-Protein-Coupled - chemistry
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - physiology
Signal Transduction - drug effects
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Summary:Designer receptors exclusively activated by designer drugs (DREADDs) have proven to be highly effective neuromodulatory tools for the investigation of neural circuits underlying behavioral outputs. They exhibit a number of advantages: they rely on cell-specific manipulations through canonical intracellular signaling pathways, they are easy and cost-effective to implement in a laboratory setting, and they are easily scalable for single-region or full-brain manipulations. On the other hand, DREADDs rely on ligand-G-protein-coupled receptor interactions, leading to coarse temporal dynamics. In this review we will provide a brief overview of DREADDs, their implementation, and the advantages and disadvantages of their use in animal systems. We also will provide numerous examples of their use across a broad variety of biomedical research fields.
ISSN:0270-6474
1529-2401
DOI:10.1523/jneurosci.1333-16.2016