Association between hyperglycaemic crisis and long-term major adverse cardiovascular events: a nationwide population-based, propensity score-matched, cohort study

Hyperglycaemic crisis was associated with significant intrahospital morbidity and mortality. However, the association between hyperglycaemic crisis and long-term cardiovascular outcomes remained unknown. This study aimed to investigate the association between hyperglycaemic crisis and subsequent lon...

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Bibliographic Details
Published in:BMJ open 2016-08, Vol.6 (8), p.e012233-e012233
Main Authors: Chang, Li-Hsin, Lin, Liang-Yu, Tsai, Ming-Tsun, How, Chorng-Kuang, Chiang, Jen-Huai, Hsieh, Vivian Chia-Rong, Hu, Sung-Yuan, Hsieh, Ming-Shun
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Age Factors
Aged
Anticoagulants
Cardiovascular Diseases - epidemiology
Case-Control Studies
Chronic obstructive pulmonary disease
Cohort analysis
Cohort Studies
Comorbidity
Diabetes
Diabetes and Endocrinology
Diabetes Complications - epidemiology
Diabetic ketoacidosis
Female
Gender
Health insurance
Hospitalization
Humans
Hyperglycemia
Hyperglycemia - epidemiology
Hyperglycemia - mortality
Hypertension
Incidence
Male
Middle Aged
Mortality
Population
Population-based studies
Propensity Score
Proportional Hazards Models
Risk Factors
Urbanization
Variables
Young Adult
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Summary:Hyperglycaemic crisis was associated with significant intrahospital morbidity and mortality. However, the association between hyperglycaemic crisis and long-term cardiovascular outcomes remained unknown. This study aimed to investigate the association between hyperglycaemic crisis and subsequent long-term major adverse cardiovascular events (MACEs). This population-based cohort study was conducted using data from Taiwan's National Health Insurance Research Database for the period of 1996-2012. A total of 2171 diabetic patients with hyperglycaemic crisis fit the inclusion criteria. Propensity score matching was used to match the baseline characteristics of the study cohort to construct a comparison cohort which comprised 8684 diabetic patients without hyperglycaemic crisis. The risk of long-term MACEs was compared between the two cohorts. Six hundred and seventy-six MACEs occurred in the study cohort and the event rate was higher than that in the comparison cohort (31.1% vs 24.1%, p
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2016-012233