Serum pepsinogen I and II concentrations and IgG antibody to Helicobacter pylori in dyspeptic patients

AIMS--To investigate the association between histologically confirmed gastritis, carriage of Helicobacter pylori and pepsinogen (PG) I and PG II concentrations. METHODS--Prospective study of 81 dyspeptic patients undergoing upper gastrointestinal endoscopy was made. The extent of gastric mucosal inf...

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Bibliographic Details
Published in:Journal of clinical pathology 1993-09, Vol.46 (9), p.826-828
Main Authors: Biasco, G, Paganelli, G M, Vaira, D, Holton, J, Di Febo, G, Brillanti, S, Miglioli, M, Barbara, L, Samloff, I M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Bacterial - blood
Bacteriological methods and techniques used in bacteriology
Bacteriology
Biological and medical sciences
Dyspepsia - blood
Dyspepsia - immunology
Dyspepsia - microbiology
Female
Fundamental and applied biological sciences. Psychology
Gastritis - immunology
Gastritis - microbiology
Helicobacter Infections - immunology
Helicobacter pylori - immunology
Humans
Immunoglobulin G - blood
Male
Microbiology
Middle Aged
Pepsinogens - blood
Prospective Studies
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Summary:AIMS--To investigate the association between histologically confirmed gastritis, carriage of Helicobacter pylori and pepsinogen (PG) I and PG II concentrations. METHODS--Prospective study of 81 dyspeptic patients undergoing upper gastrointestinal endoscopy was made. The extent of gastric mucosal inflammation and the presence of H pylori was determined, and serology to evaluate PG I and II concentrations and IgG titres to H pylori was carried out. RESULTS--The presence of H pylori was strongly correlated with high IgG antibody titres to H pylori and gastritis. Patients who were H pylori positive had significantly higher PG I and PG II concentrations and a significantly lower PG I:PG II ratio than patients who were negative for H pylori. In 13 patients with duodenal ulcer and H pylori positive gastritis serum PG I concentrations were significantly higher than in H pylori positive patients without duodenal ulcer. Significant correlations were found between the age of patients and serum PG II, the PG I:PG II ratio, IgG antibodies to H pylori, the severity of body gastritis and H pylori infection, and between the degree of gastritis in the body of the stomach and the PG II concentration. CONCLUSIONS--Serum PG I and II concentrations, together with a fall in the PG I:PG II ratio, could be used as predictors of H pylori infection as well as serum IgG antibody response to H pylori.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.46.9.826