Effects of Granulocyte Colony-Stimulating Factor (GCSF) on Persistent Thin Endometrium in Frozen Embryo Transfer (FET) Cycles

Objective To predict the effectiveness of granulocyte colony-stimulating factor (GCSF) in the treatment of persistent thin endometrium resistant to other treatments in frozen embryo transfer (FET) cycles. Study Design This is a hospital-based prospective study. Patients Thirty-five women with persis...

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Published in:Journal of obstetrics and gynaecology of India 2016-10, Vol.66 (Suppl 1), p.407-411
Main Authors: Mishra, Vineet V., Choudhary, Sumesh, Sharma, Urmila, Aggarwal, Rohina, Agarwal, Ritu, Gandhi, Khushali, Goraniya, Nilesh
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Language:English
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Gynecology
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
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cited_by cdi_FETCH-LOGICAL-c442t-6285395e61a8c1a01cb2d4643d07229e8577b152f143687a9faa455dfedc35ca3
cites cdi_FETCH-LOGICAL-c442t-6285395e61a8c1a01cb2d4643d07229e8577b152f143687a9faa455dfedc35ca3
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container_issue Suppl 1
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container_title Journal of obstetrics and gynaecology of India
container_volume 66
creator Mishra, Vineet V.
Choudhary, Sumesh
Sharma, Urmila
Aggarwal, Rohina
Agarwal, Ritu
Gandhi, Khushali
Goraniya, Nilesh
description Objective To predict the effectiveness of granulocyte colony-stimulating factor (GCSF) in the treatment of persistent thin endometrium resistant to other treatments in frozen embryo transfer (FET) cycles. Study Design This is a hospital-based prospective study. Patients Thirty-five women with persistent thin endometrium (
doi_str_mv 10.1007/s13224-015-0775-9
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Study Design This is a hospital-based prospective study. Patients Thirty-five women with persistent thin endometrium (&lt;7 mm) resistant to standard treatments were involved in this study. Intervention(s) Intrauterine infusion of GCSF (300 mcg/1 ml) was done in patients with thin endometrium on day 14 of FET cycles, and their endometrial thicknesses were measured after 48 h of infusion. Main Outcome Measures The primary outcome was an increase in endometrial thickness and the secondary outcome measures were chemical and clinical pregnancies. Results The endometrial thickness increased from 5.86 ± 0.58 to 6.58 ± 0.84 mm after GCSF infusion. In 19 of the 35 participants (54.28 %) endometrial thickness increased to ≥7 mm and they subsequently underwent embryo transfer. Of these, 3 (15.78 %) patients had chemical pregnancy, but there was no clinical pregnancy. In 16 participants, embryo transfer was canceled in view of insufficient endometrial thickness (&lt;7 mm). Conclusion GCSF caused a small increase in endometrial thickness in women with persistent thin endometrium, but there was no improvement in their pregnancy rates.</description><identifier>ISSN: 0971-9202</identifier><identifier>EISSN: 0975-6434</identifier><identifier>DOI: 10.1007/s13224-015-0775-9</identifier><identifier>PMID: 27651638</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Gynecology ; Medicine ; Medicine &amp; Public Health ; Obstetrics/Perinatology/Midwifery ; Original ; Original Article</subject><ispartof>Journal of obstetrics and gynaecology of India, 2016-10, Vol.66 (Suppl 1), p.407-411</ispartof><rights>Federation of Obstetric &amp; Gynecological Societies of India 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-6285395e61a8c1a01cb2d4643d07229e8577b152f143687a9faa455dfedc35ca3</citedby><cites>FETCH-LOGICAL-c442t-6285395e61a8c1a01cb2d4643d07229e8577b152f143687a9faa455dfedc35ca3</cites><orcidid>0000-0002-3249-694X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016412/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016412/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27651638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mishra, Vineet V.</creatorcontrib><creatorcontrib>Choudhary, Sumesh</creatorcontrib><creatorcontrib>Sharma, Urmila</creatorcontrib><creatorcontrib>Aggarwal, Rohina</creatorcontrib><creatorcontrib>Agarwal, Ritu</creatorcontrib><creatorcontrib>Gandhi, Khushali</creatorcontrib><creatorcontrib>Goraniya, Nilesh</creatorcontrib><title>Effects of Granulocyte Colony-Stimulating Factor (GCSF) on Persistent Thin Endometrium in Frozen Embryo Transfer (FET) Cycles</title><title>Journal of obstetrics and gynaecology of India</title><addtitle>J Obstet Gynecol India</addtitle><addtitle>J Obstet Gynaecol India</addtitle><description>Objective To predict the effectiveness of granulocyte colony-stimulating factor (GCSF) in the treatment of persistent thin endometrium resistant to other treatments in frozen embryo transfer (FET) cycles. Study Design This is a hospital-based prospective study. Patients Thirty-five women with persistent thin endometrium (&lt;7 mm) resistant to standard treatments were involved in this study. Intervention(s) Intrauterine infusion of GCSF (300 mcg/1 ml) was done in patients with thin endometrium on day 14 of FET cycles, and their endometrial thicknesses were measured after 48 h of infusion. Main Outcome Measures The primary outcome was an increase in endometrial thickness and the secondary outcome measures were chemical and clinical pregnancies. Results The endometrial thickness increased from 5.86 ± 0.58 to 6.58 ± 0.84 mm after GCSF infusion. In 19 of the 35 participants (54.28 %) endometrial thickness increased to ≥7 mm and they subsequently underwent embryo transfer. Of these, 3 (15.78 %) patients had chemical pregnancy, but there was no clinical pregnancy. In 16 participants, embryo transfer was canceled in view of insufficient endometrial thickness (&lt;7 mm). Conclusion GCSF caused a small increase in endometrial thickness in women with persistent thin endometrium, but there was no improvement in their pregnancy rates.</description><subject>Gynecology</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Original</subject><subject>Original Article</subject><issn>0971-9202</issn><issn>0975-6434</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9UUtPHSEUJk1Nff6AbhqWuhgLDI-ZjUkzufdqYtIm3q4Jl4ErZgYsME2mif9d9FqjG1cczvc4Bz4AvmJ0jhES3xOuCaEVwqxCQrCq_QQOUFsKTmv6-bnGVUsQ2QeHKd0hxAQi9AvYJ4IzzOvmADwsrDU6JxgsXEXlpyHoORvYhSH4ubrJbpwGlZ3fwqXSOUR4uupulmcwePjLxORSNj7D9a3zcOH7MJoc3TTCcl3G8M-U7riJc4DrYp6sKfrlYn0Gu1kPJh2DPauGZE5eziPwu6DdZXX9c3XV_biuNKUkV5w0rG6Z4Vg1GiuE9Yb0tDyyR4KQ1jRMiA1mxGJa80ao1ipFGeut6XXNtKqPwMXO937ajKVZVo5qkPfRjSrOMign3yPe3cpt-CsZwpxiUgxOXwxi-DOZlOXokjbDoLwJU5K4KUHwlnBUqHhH1TGkFI19HYORfIpN7mKTJTb5FJtsi-bb2_1eFf9zKgSyI6QC-a2J8i5M0Zc_-8D1ET-Eo8g</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Mishra, Vineet V.</creator><creator>Choudhary, Sumesh</creator><creator>Sharma, Urmila</creator><creator>Aggarwal, Rohina</creator><creator>Agarwal, Ritu</creator><creator>Gandhi, Khushali</creator><creator>Goraniya, Nilesh</creator><general>Springer India</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3249-694X</orcidid></search><sort><creationdate>20161001</creationdate><title>Effects of Granulocyte Colony-Stimulating Factor (GCSF) on Persistent Thin Endometrium in Frozen Embryo Transfer (FET) Cycles</title><author>Mishra, Vineet V. ; Choudhary, Sumesh ; Sharma, Urmila ; Aggarwal, Rohina ; Agarwal, Ritu ; Gandhi, Khushali ; Goraniya, Nilesh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-6285395e61a8c1a01cb2d4643d07229e8577b152f143687a9faa455dfedc35ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Gynecology</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Original</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mishra, Vineet V.</creatorcontrib><creatorcontrib>Choudhary, Sumesh</creatorcontrib><creatorcontrib>Sharma, Urmila</creatorcontrib><creatorcontrib>Aggarwal, Rohina</creatorcontrib><creatorcontrib>Agarwal, Ritu</creatorcontrib><creatorcontrib>Gandhi, Khushali</creatorcontrib><creatorcontrib>Goraniya, Nilesh</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of obstetrics and gynaecology of India</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mishra, Vineet V.</au><au>Choudhary, Sumesh</au><au>Sharma, Urmila</au><au>Aggarwal, Rohina</au><au>Agarwal, Ritu</au><au>Gandhi, Khushali</au><au>Goraniya, Nilesh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Granulocyte Colony-Stimulating Factor (GCSF) on Persistent Thin Endometrium in Frozen Embryo Transfer (FET) Cycles</atitle><jtitle>Journal of obstetrics and gynaecology of India</jtitle><stitle>J Obstet Gynecol India</stitle><addtitle>J Obstet Gynaecol India</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>66</volume><issue>Suppl 1</issue><spage>407</spage><epage>411</epage><pages>407-411</pages><issn>0971-9202</issn><eissn>0975-6434</eissn><abstract>Objective To predict the effectiveness of granulocyte colony-stimulating factor (GCSF) in the treatment of persistent thin endometrium resistant to other treatments in frozen embryo transfer (FET) cycles. Study Design This is a hospital-based prospective study. Patients Thirty-five women with persistent thin endometrium (&lt;7 mm) resistant to standard treatments were involved in this study. Intervention(s) Intrauterine infusion of GCSF (300 mcg/1 ml) was done in patients with thin endometrium on day 14 of FET cycles, and their endometrial thicknesses were measured after 48 h of infusion. Main Outcome Measures The primary outcome was an increase in endometrial thickness and the secondary outcome measures were chemical and clinical pregnancies. Results The endometrial thickness increased from 5.86 ± 0.58 to 6.58 ± 0.84 mm after GCSF infusion. In 19 of the 35 participants (54.28 %) endometrial thickness increased to ≥7 mm and they subsequently underwent embryo transfer. Of these, 3 (15.78 %) patients had chemical pregnancy, but there was no clinical pregnancy. In 16 participants, embryo transfer was canceled in view of insufficient endometrial thickness (&lt;7 mm). Conclusion GCSF caused a small increase in endometrial thickness in women with persistent thin endometrium, but there was no improvement in their pregnancy rates.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>27651638</pmid><doi>10.1007/s13224-015-0775-9</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-3249-694X</orcidid><oa>free_for_read</oa></addata></record>
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subjects Gynecology
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Original
Original Article
title Effects of Granulocyte Colony-Stimulating Factor (GCSF) on Persistent Thin Endometrium in Frozen Embryo Transfer (FET) Cycles
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