24-hour-restraint stress induces long-term depressive-like phenotypes in mice

There is an increasing risk of mental disorders, such as acute stress disorder (ASD), post-traumatic stress disorder (PTSD) and depression among survivors who were trapped in rubble during earthquake. Such long-term impaction of a single acute restraint stress has not been extensively explored. In t...

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Published in:Scientific reports 2016-09, Vol.6 (1), p.32935-32935, Article 32935
Main Authors: Chu, Xixia, Zhou, Ying, Hu, Zhiqiang, Lou, Jingyu, Song, Wei, Li, Jing, Liang, Xiao, Chen, Chen, Wang, Shuai, Yang, Beimeng, Chen, Lei, Zhang, Xu, Song, Jinjing, Dong, Yujie, Chen, Shiqing, He, Lin, Xie, Qingguo, Chen, Xiaoping, Li, Weidong
Format: Article
Language:English
Subjects:
631/378
631/378/1689/1414
Animals
Behavior, Animal
Brain - physiopathology
Circadian rhythm
Depression - etiology
Depression - pathology
Disease Models, Animal
Earthquakes
Fluoxetine
Gene Expression Profiling
Hippocampus
Humanities and Social Sciences
Mental depression
Mental disorders
Mice
Mood
multidisciplinary
Neurogenesis
Post traumatic stress disorder
Restraint, Physical
Science
Seismic activity
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Summary:There is an increasing risk of mental disorders, such as acute stress disorder (ASD), post-traumatic stress disorder (PTSD) and depression among survivors who were trapped in rubble during earthquake. Such long-term impaction of a single acute restraint stress has not been extensively explored. In this study, we subjected mice to 24-hour-restraint to simulate the trapping episode, and investigated the acute (2 days after the restraint) and long-term (35 days after the restraint) impacts. Surprisingly, we found that the mice displayed depression-like behaviors, decreased glucose uptake in brain and reduced adult hippocampal neurogenesis 35 days after the restraint. Differential expression profiling based on microarrays suggested that genes and pathways related to depression and other mental disorders were differentially expressed in both PFC and hippocampus. Furthermore, the depression-like phenotypes induced by 24-hour-restraint could be reversed by fluoxetine, a type of antidepressant drug. These findings demonstrated that a single severe stressful event could produce long-term depressive-like phenotypes. Moreover, the 24-hour-restraint stress mice could also be used for further studies on mood disorders.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep32935